Cardioversion of atrial fibrillation in obese patients: Results from the Cardioversion-BMI randomized controlled trial

Aleksandr Voskoboinik, Jeremy Moskovitch, George Plunkett, Jason Bloom, Geoffrey Wong, Chrishan Nalliah, Sandeep Prabhu, Hariharan Sugumar, Ramanathan Paramasweran, Alex McLellan, Liang Han Ling, Cheng Yee Goh, Samer Noaman, Himawan Fernando, Michael Wong, Andrew J. Taylor, Jonathan M. Kalman, Peter M. Kistler

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aims: Obesity is associated with higher electrical cardioversion (ECV) failure in persistent atrial fibrillation (PeAF). For ease-of-use, many centers prefer patches over paddles. We assessed the optimum modality and shock vector, as well as the safety and efficacy of the Manual Pressure Augmentation (MPA) technique. Methods: Patients with obesity (BMI ≥ 30) and PeAF undergoing ECV using a biphasic defibrillator were randomized into one of four arms by modality (adhesive patches or handheld paddles) and shock vector (anteroposterior [AP] or anteroapical [AA]). If the first two shocks (100 and 200 J) failed, then patients received a 200-J shock using the alternative modality (patch or paddle). Shock vector remained unchanged. In an observational substudy, 20 patients with BMI of 35 or more, and who failed ECV at 200 J using both patches/paddles underwent a trial of MPA. Results: In total, 125 patients were randomized between July 2016 and March 2018. First or second shock success was 43 of 63 (68.2%) for patches and 56 of 62 (90.3%) for paddles (P = 0.002). There were 20 crossovers from patches to paddles (12 of 20 third shock success with paddles) and six crossovers from paddles to patches (three of six third shock success with patches). Paddles successfully cardioverted 68 of 82 patients compared with 46 of 69 using patches (82.9% vs 66.7%; P = 0.02). Shock vector did not influence first or second shock success rates (82.0% AP vs 76.6% AA; P = 0.46). MPA was successful in 16 of 20 (80%) who failed in both (patches/paddles), with 360 J required in six of seven cases. Conclusion: Routine use of adhesive patches at 200 J is inadequate in obesity. Strategies that improve success include the use of paddles, MPA, and escalation to 360 J.

Original languageEnglish
Pages (from-to)155-161
Number of pages7
JournalJournal of Cardiovascular Electrophysiology
Volume30
Issue number2
DOIs
Publication statusPublished - 1 Feb 2019
Externally publishedYes

Keywords

  • atrial fibrillation
  • direct current cardioversion
  • left atrium
  • obesity
  • transthoracic impedance

Cite this

Voskoboinik, Aleksandr ; Moskovitch, Jeremy ; Plunkett, George ; Bloom, Jason ; Wong, Geoffrey ; Nalliah, Chrishan ; Prabhu, Sandeep ; Sugumar, Hariharan ; Paramasweran, Ramanathan ; McLellan, Alex ; Ling, Liang Han ; Goh, Cheng Yee ; Noaman, Samer ; Fernando, Himawan ; Wong, Michael ; Taylor, Andrew J. ; Kalman, Jonathan M. ; Kistler, Peter M. / Cardioversion of atrial fibrillation in obese patients : Results from the Cardioversion-BMI randomized controlled trial. In: Journal of Cardiovascular Electrophysiology. 2019 ; Vol. 30, No. 2. pp. 155-161.
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title = "Cardioversion of atrial fibrillation in obese patients: Results from the Cardioversion-BMI randomized controlled trial",
abstract = "Aims: Obesity is associated with higher electrical cardioversion (ECV) failure in persistent atrial fibrillation (PeAF). For ease-of-use, many centers prefer patches over paddles. We assessed the optimum modality and shock vector, as well as the safety and efficacy of the Manual Pressure Augmentation (MPA) technique. Methods: Patients with obesity (BMI ≥ 30) and PeAF undergoing ECV using a biphasic defibrillator were randomized into one of four arms by modality (adhesive patches or handheld paddles) and shock vector (anteroposterior [AP] or anteroapical [AA]). If the first two shocks (100 and 200 J) failed, then patients received a 200-J shock using the alternative modality (patch or paddle). Shock vector remained unchanged. In an observational substudy, 20 patients with BMI of 35 or more, and who failed ECV at 200 J using both patches/paddles underwent a trial of MPA. Results: In total, 125 patients were randomized between July 2016 and March 2018. First or second shock success was 43 of 63 (68.2{\%}) for patches and 56 of 62 (90.3{\%}) for paddles (P = 0.002). There were 20 crossovers from patches to paddles (12 of 20 third shock success with paddles) and six crossovers from paddles to patches (three of six third shock success with patches). Paddles successfully cardioverted 68 of 82 patients compared with 46 of 69 using patches (82.9{\%} vs 66.7{\%}; P = 0.02). Shock vector did not influence first or second shock success rates (82.0{\%} AP vs 76.6{\%} AA; P = 0.46). MPA was successful in 16 of 20 (80{\%}) who failed in both (patches/paddles), with 360 J required in six of seven cases. Conclusion: Routine use of adhesive patches at 200 J is inadequate in obesity. Strategies that improve success include the use of paddles, MPA, and escalation to 360 J.",
keywords = "atrial fibrillation, direct current cardioversion, left atrium, obesity, transthoracic impedance",
author = "Aleksandr Voskoboinik and Jeremy Moskovitch and George Plunkett and Jason Bloom and Geoffrey Wong and Chrishan Nalliah and Sandeep Prabhu and Hariharan Sugumar and Ramanathan Paramasweran and Alex McLellan and Ling, {Liang Han} and Goh, {Cheng Yee} and Samer Noaman and Himawan Fernando and Michael Wong and Taylor, {Andrew J.} and Kalman, {Jonathan M.} and Kistler, {Peter M.}",
year = "2019",
month = "2",
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language = "English",
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Voskoboinik, A, Moskovitch, J, Plunkett, G, Bloom, J, Wong, G, Nalliah, C, Prabhu, S, Sugumar, H, Paramasweran, R, McLellan, A, Ling, LH, Goh, CY, Noaman, S, Fernando, H, Wong, M, Taylor, AJ, Kalman, JM & Kistler, PM 2019, 'Cardioversion of atrial fibrillation in obese patients: Results from the Cardioversion-BMI randomized controlled trial' Journal of Cardiovascular Electrophysiology, vol. 30, no. 2, pp. 155-161. https://doi.org/10.1111/jce.13786

Cardioversion of atrial fibrillation in obese patients : Results from the Cardioversion-BMI randomized controlled trial. / Voskoboinik, Aleksandr; Moskovitch, Jeremy; Plunkett, George; Bloom, Jason; Wong, Geoffrey; Nalliah, Chrishan; Prabhu, Sandeep; Sugumar, Hariharan; Paramasweran, Ramanathan; McLellan, Alex; Ling, Liang Han; Goh, Cheng Yee; Noaman, Samer; Fernando, Himawan; Wong, Michael; Taylor, Andrew J.; Kalman, Jonathan M.; Kistler, Peter M.

In: Journal of Cardiovascular Electrophysiology, Vol. 30, No. 2, 01.02.2019, p. 155-161.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Cardioversion of atrial fibrillation in obese patients

T2 - Results from the Cardioversion-BMI randomized controlled trial

AU - Voskoboinik, Aleksandr

AU - Moskovitch, Jeremy

AU - Plunkett, George

AU - Bloom, Jason

AU - Wong, Geoffrey

AU - Nalliah, Chrishan

AU - Prabhu, Sandeep

AU - Sugumar, Hariharan

AU - Paramasweran, Ramanathan

AU - McLellan, Alex

AU - Ling, Liang Han

AU - Goh, Cheng Yee

AU - Noaman, Samer

AU - Fernando, Himawan

AU - Wong, Michael

AU - Taylor, Andrew J.

AU - Kalman, Jonathan M.

AU - Kistler, Peter M.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Aims: Obesity is associated with higher electrical cardioversion (ECV) failure in persistent atrial fibrillation (PeAF). For ease-of-use, many centers prefer patches over paddles. We assessed the optimum modality and shock vector, as well as the safety and efficacy of the Manual Pressure Augmentation (MPA) technique. Methods: Patients with obesity (BMI ≥ 30) and PeAF undergoing ECV using a biphasic defibrillator were randomized into one of four arms by modality (adhesive patches or handheld paddles) and shock vector (anteroposterior [AP] or anteroapical [AA]). If the first two shocks (100 and 200 J) failed, then patients received a 200-J shock using the alternative modality (patch or paddle). Shock vector remained unchanged. In an observational substudy, 20 patients with BMI of 35 or more, and who failed ECV at 200 J using both patches/paddles underwent a trial of MPA. Results: In total, 125 patients were randomized between July 2016 and March 2018. First or second shock success was 43 of 63 (68.2%) for patches and 56 of 62 (90.3%) for paddles (P = 0.002). There were 20 crossovers from patches to paddles (12 of 20 third shock success with paddles) and six crossovers from paddles to patches (three of six third shock success with patches). Paddles successfully cardioverted 68 of 82 patients compared with 46 of 69 using patches (82.9% vs 66.7%; P = 0.02). Shock vector did not influence first or second shock success rates (82.0% AP vs 76.6% AA; P = 0.46). MPA was successful in 16 of 20 (80%) who failed in both (patches/paddles), with 360 J required in six of seven cases. Conclusion: Routine use of adhesive patches at 200 J is inadequate in obesity. Strategies that improve success include the use of paddles, MPA, and escalation to 360 J.

AB - Aims: Obesity is associated with higher electrical cardioversion (ECV) failure in persistent atrial fibrillation (PeAF). For ease-of-use, many centers prefer patches over paddles. We assessed the optimum modality and shock vector, as well as the safety and efficacy of the Manual Pressure Augmentation (MPA) technique. Methods: Patients with obesity (BMI ≥ 30) and PeAF undergoing ECV using a biphasic defibrillator were randomized into one of four arms by modality (adhesive patches or handheld paddles) and shock vector (anteroposterior [AP] or anteroapical [AA]). If the first two shocks (100 and 200 J) failed, then patients received a 200-J shock using the alternative modality (patch or paddle). Shock vector remained unchanged. In an observational substudy, 20 patients with BMI of 35 or more, and who failed ECV at 200 J using both patches/paddles underwent a trial of MPA. Results: In total, 125 patients were randomized between July 2016 and March 2018. First or second shock success was 43 of 63 (68.2%) for patches and 56 of 62 (90.3%) for paddles (P = 0.002). There were 20 crossovers from patches to paddles (12 of 20 third shock success with paddles) and six crossovers from paddles to patches (three of six third shock success with patches). Paddles successfully cardioverted 68 of 82 patients compared with 46 of 69 using patches (82.9% vs 66.7%; P = 0.02). Shock vector did not influence first or second shock success rates (82.0% AP vs 76.6% AA; P = 0.46). MPA was successful in 16 of 20 (80%) who failed in both (patches/paddles), with 360 J required in six of seven cases. Conclusion: Routine use of adhesive patches at 200 J is inadequate in obesity. Strategies that improve success include the use of paddles, MPA, and escalation to 360 J.

KW - atrial fibrillation

KW - direct current cardioversion

KW - left atrium

KW - obesity

KW - transthoracic impedance

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