Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice

Beza Abegaz; Pamela J Davern; Kristy L Jackson; Thu-Phuc Nguyen-Huu; Jaspreet K Bassi; Angela Connelly; Yan-Ting Choong; Andrew M Allen; Geoff Albert Head

doi:10.1093/cvr/cvt183

Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice

Beza Abegaz, Pamela J Davern, Kristy L Jackson, Thu-Phuc Nguyen-Huu, Jaspreet K Bassi, Angela Connelly, Yan-Ting Choong, Andrew M Allen, Geoff Albert Head

Pharmacology

Research output: Contribution to journal › Article › Research › peer-review

12 Citations (Scopus)

Abstract

AIMS: The nucleus of the solitary tract (NTS) is important for cardiovascular regulation and contains angiotensin type 1A receptors (AT1AR). To assess function, we examined the effect of expressing in AT1AR in the NTS of mice lacking these receptors. METHODS AND RESULTS: Bilateral microinjections of lentivirus expressing AT1AR (AT1Av mice, n=6) or green fluorescent protein (GFPv, n=8, control) under the control of the PRSx8 promotor, were made into the NTS of AT1AR null mice (AT1A-/-). Telemetry devices recorded blood pressure (BP), heart rate (HR) and locomotor activity. Expression of AT1AR in the NTS increased BP by 11.2+/-4 mmHg (P

Original language	English
Pages (from-to)	181 - 191
Number of pages	11
Journal	Cardiovascular Research
Volume	100
Issue number	2
DOIs	https://doi.org/10.1093/cvr/cvt183
Publication status	Published - 2013

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title = "Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice",

abstract = "AIMS: The nucleus of the solitary tract (NTS) is important for cardiovascular regulation and contains angiotensin type 1A receptors (AT1AR). To assess function, we examined the effect of expressing in AT1AR in the NTS of mice lacking these receptors. METHODS AND RESULTS: Bilateral microinjections of lentivirus expressing AT1AR (AT1Av mice, n=6) or green fluorescent protein (GFPv, n=8, control) under the control of the PRSx8 promotor, were made into the NTS of AT1AR null mice (AT1A-/-). Telemetry devices recorded blood pressure (BP), heart rate (HR) and locomotor activity. Expression of AT1AR in the NTS increased BP by 11.2+/-4 mmHg (P",

author = "Beza Abegaz and Davern, {Pamela J} and Jackson, {Kristy L} and Thu-Phuc Nguyen-Huu and Bassi, {Jaspreet K} and Angela Connelly and Yan-Ting Choong and Allen, {Andrew M} and Head, {Geoff Albert}",

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doi = "10.1093/cvr/cvt183",

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T1 - Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice

AU - Abegaz, Beza

AU - Davern, Pamela J

AU - Jackson, Kristy L

AU - Nguyen-Huu, Thu-Phuc

AU - Bassi, Jaspreet K

AU - Connelly, Angela

AU - Choong, Yan-Ting

AU - Allen, Andrew M

AU - Head, Geoff Albert

PY - 2013

Y1 - 2013

N2 - AIMS: The nucleus of the solitary tract (NTS) is important for cardiovascular regulation and contains angiotensin type 1A receptors (AT1AR). To assess function, we examined the effect of expressing in AT1AR in the NTS of mice lacking these receptors. METHODS AND RESULTS: Bilateral microinjections of lentivirus expressing AT1AR (AT1Av mice, n=6) or green fluorescent protein (GFPv, n=8, control) under the control of the PRSx8 promotor, were made into the NTS of AT1AR null mice (AT1A-/-). Telemetry devices recorded blood pressure (BP), heart rate (HR) and locomotor activity. Expression of AT1AR in the NTS increased BP by 11.2+/-4 mmHg (P

AB - AIMS: The nucleus of the solitary tract (NTS) is important for cardiovascular regulation and contains angiotensin type 1A receptors (AT1AR). To assess function, we examined the effect of expressing in AT1AR in the NTS of mice lacking these receptors. METHODS AND RESULTS: Bilateral microinjections of lentivirus expressing AT1AR (AT1Av mice, n=6) or green fluorescent protein (GFPv, n=8, control) under the control of the PRSx8 promotor, were made into the NTS of AT1AR null mice (AT1A-/-). Telemetry devices recorded blood pressure (BP), heart rate (HR) and locomotor activity. Expression of AT1AR in the NTS increased BP by 11.2+/-4 mmHg (P

UR - http://cardiovascres.oxfordjournals.org/content/100/2/181.full.pdf+html

U2 - 10.1093/cvr/cvt183

DO - 10.1093/cvr/cvt183

M3 - Article

SN - 0008-6363

VL - 100

SP - 181

EP - 191

JO - Cardiovascular Research

JF - Cardiovascular Research

IS - 2

ER -

Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice

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