Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice

Beza Abegaz, Pamela J Davern, Kristy L Jackson, Thu-Phuc Nguyen-Huu, Jaspreet K Bassi, Angela Connelly, Yan-Ting Choong, Andrew M Allen, Geoff Albert Head

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Abstract

AIMS: The nucleus of the solitary tract (NTS) is important for cardiovascular regulation and contains angiotensin type 1A receptors (AT1AR). To assess function, we examined the effect of expressing in AT1AR in the NTS of mice lacking these receptors. METHODS AND RESULTS: Bilateral microinjections of lentivirus expressing AT1AR (AT1Av mice, n=6) or green fluorescent protein (GFPv, n=8, control) under the control of the PRSx8 promotor, were made into the NTS of AT1AR null mice (AT1A-/-). Telemetry devices recorded blood pressure (BP), heart rate (HR) and locomotor activity. Expression of AT1AR in the NTS increased BP by 11.2+/-4 mmHg (P
Original languageEnglish
Pages (from-to)181 - 191
Number of pages11
JournalCardiovascular Research
Volume100
Issue number2
DOIs
Publication statusPublished - 2013

Cite this

Abegaz, B., Davern, P. J., Jackson, K. L., Nguyen-Huu, T-P., Bassi, J. K., Connelly, A., Choong, Y-T., Allen, A. M., & Head, G. A. (2013). Cardiovascular role of angiotensin type1A receptors in the nucleus of the solitary tract of mice. Cardiovascular Research, 100(2), 181 - 191. https://doi.org/10.1093/cvr/cvt183