TY - CHAP
T1 - Cardiovascular PET-CT
AU - Croteau, Etienne
AU - Klein, Ran
AU - Renaud, Jennifer M.
AU - Premaratne, Manuja
AU - De Kemp, Robert A.
PY - 2017
Y1 - 2017
N2 - Positron emission tomography (PET) is the leading tool in nuclear cardiology for noninvasive assessment of molecular function. Images are obtained via detection of positrons emitted from the decay of an injected radiotracer. Radiotracers are either short-lived isotopes themselves, such as 82Rb, or isotopes that have been incorporated into biological or drug compounds, such as 18F-fluoro-deoxyglucose or 11C-methyl-losartan, respectively. The amount of tracer injected is low enough such that it does not affect the physiological process being imaged. Most isotopes are produced in a cyclotron and undergo radiochemical synthesis to be incorporated into a tracer molecule, requiring an onsite or local cyclotron due to the short half-lives. There has been a shift toward simpler and more cost-effective onsite alternatives, such as the generator-produced tracer 82Rb. Some of the most common clinical and research-based cardiac PET tracers, their characteristics, applications, and the associated imaging protocols are listed in Table 2.1 (Zober et al. 2006; Thackeray and Bengel 2013; Danad, Raijimakers, and Knaapen 2013).
AB - Positron emission tomography (PET) is the leading tool in nuclear cardiology for noninvasive assessment of molecular function. Images are obtained via detection of positrons emitted from the decay of an injected radiotracer. Radiotracers are either short-lived isotopes themselves, such as 82Rb, or isotopes that have been incorporated into biological or drug compounds, such as 18F-fluoro-deoxyglucose or 11C-methyl-losartan, respectively. The amount of tracer injected is low enough such that it does not affect the physiological process being imaged. Most isotopes are produced in a cyclotron and undergo radiochemical synthesis to be incorporated into a tracer molecule, requiring an onsite or local cyclotron due to the short half-lives. There has been a shift toward simpler and more cost-effective onsite alternatives, such as the generator-produced tracer 82Rb. Some of the most common clinical and research-based cardiac PET tracers, their characteristics, applications, and the associated imaging protocols are listed in Table 2.1 (Zober et al. 2006; Thackeray and Bengel 2013; Danad, Raijimakers, and Knaapen 2013).
UR - http://www.scopus.com/inward/record.url?scp=85054235401&partnerID=8YFLogxK
U2 - 10.1201/9781315374031
DO - 10.1201/9781315374031
M3 - Chapter (Book)
AN - SCOPUS:85054235401
SN - 9781466595378
T3 - Imaging in Medical Diagnosis and Therapy
SP - 27
EP - 56
BT - Hybrid Imaging in Cardiovascular Medicine
A2 - Liu, Yi-Hwa
A2 - Sinusas, Albert J
PB - CRC Press
CY - Boca Raton FL USA
ER -