Abstract
Background Caffeinated energy drinks may trigger serious cardiac effects. The aim of this study was to determine the cardiovascular effects of caffeinated energy drink consumption in patients with familial long QT syndrome (LQTS). Methods and Results From 2014–2016, 24 LQTS patients aged 16–50 years were recruited to a randomized, double-blind, cross-over study of energy drink (ED) versus control (CD) with participants acting as their own controls (one week washout). The primary study outcome was an increase in corrected QT interval (QTc) by > 20ms. Secondary outcomes were changes in systolic and diastolic blood pressure. In 24 patients with LQTS (no dropout), mean age was 29 ± 9 years, 13/24 (54%) were female, and 8/24 (33%) were probands. Intention to treat analysis revealed no significant change in QTc with ED compared with CD (12 ± 28 ms vs 16 ± 27 ms, 3% vs 4%, p = 0.71). The systolic and diastolic blood pressure significantly increased with ED compared to CD (peak change 7 ± 16 mmHg vs 1 ± 16 mmHg, 6% vs 0.8%, p = 0.046 and 8 ± 10 vs 2 ± 9 mmHg, 11% vs 3% p = 0.01 respectively). These changes correlated with significant increases in serum caffeine (14.6 ± 11.3 vs 0.5 ± 0.1 μmol/L, p < 0.001) and serum taurine (737 ± 199 vs -59 ± 22 μmol/L, p < 0.001). There were three patients with dangerous QTc prolongation of ≥50ms following energy drink consumption. Conclusion Caffeinated energy drinks have significant haemodynamic effects in patients with LQTS, especifically an acute increase in blood pressure. Since dangerous QTc prolongation was seen in some LQTS patients, we recommend caution in young patients with LQTS consuming energy drinks.
| Original language | English |
|---|---|
| Pages (from-to) | 150-154 |
| Number of pages | 5 |
| Journal | International Journal of Cardiology |
| Volume | 231 |
| DOIs | |
| Publication status | Published - 15 Mar 2017 |
| Externally published | Yes |
Keywords
- energy drinks
- Long QT syndrome
Cite this
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Cardiovascular Effects of Energy Drinks in Familial Long QT Syndrome : A Randomized Cross-Over Study. / Gray, Belinda; Ingles, Jodie; Medi, Caroline; Driscoll, Timothy; Semsarian, Christopher.
In: International Journal of Cardiology, Vol. 231, 15.03.2017, p. 150-154.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Cardiovascular Effects of Energy Drinks in Familial Long QT Syndrome
T2 - A Randomized Cross-Over Study
AU - Gray, Belinda
AU - Ingles, Jodie
AU - Medi, Caroline
AU - Driscoll, Timothy
AU - Semsarian, Christopher
PY - 2017/3/15
Y1 - 2017/3/15
N2 - Background Caffeinated energy drinks may trigger serious cardiac effects. The aim of this study was to determine the cardiovascular effects of caffeinated energy drink consumption in patients with familial long QT syndrome (LQTS). Methods and Results From 2014–2016, 24 LQTS patients aged 16–50 years were recruited to a randomized, double-blind, cross-over study of energy drink (ED) versus control (CD) with participants acting as their own controls (one week washout). The primary study outcome was an increase in corrected QT interval (QTc) by > 20ms. Secondary outcomes were changes in systolic and diastolic blood pressure. In 24 patients with LQTS (no dropout), mean age was 29 ± 9 years, 13/24 (54%) were female, and 8/24 (33%) were probands. Intention to treat analysis revealed no significant change in QTc with ED compared with CD (12 ± 28 ms vs 16 ± 27 ms, 3% vs 4%, p = 0.71). The systolic and diastolic blood pressure significantly increased with ED compared to CD (peak change 7 ± 16 mmHg vs 1 ± 16 mmHg, 6% vs 0.8%, p = 0.046 and 8 ± 10 vs 2 ± 9 mmHg, 11% vs 3% p = 0.01 respectively). These changes correlated with significant increases in serum caffeine (14.6 ± 11.3 vs 0.5 ± 0.1 μmol/L, p < 0.001) and serum taurine (737 ± 199 vs -59 ± 22 μmol/L, p < 0.001). There were three patients with dangerous QTc prolongation of ≥50ms following energy drink consumption. Conclusion Caffeinated energy drinks have significant haemodynamic effects in patients with LQTS, especifically an acute increase in blood pressure. Since dangerous QTc prolongation was seen in some LQTS patients, we recommend caution in young patients with LQTS consuming energy drinks.
AB - Background Caffeinated energy drinks may trigger serious cardiac effects. The aim of this study was to determine the cardiovascular effects of caffeinated energy drink consumption in patients with familial long QT syndrome (LQTS). Methods and Results From 2014–2016, 24 LQTS patients aged 16–50 years were recruited to a randomized, double-blind, cross-over study of energy drink (ED) versus control (CD) with participants acting as their own controls (one week washout). The primary study outcome was an increase in corrected QT interval (QTc) by > 20ms. Secondary outcomes were changes in systolic and diastolic blood pressure. In 24 patients with LQTS (no dropout), mean age was 29 ± 9 years, 13/24 (54%) were female, and 8/24 (33%) were probands. Intention to treat analysis revealed no significant change in QTc with ED compared with CD (12 ± 28 ms vs 16 ± 27 ms, 3% vs 4%, p = 0.71). The systolic and diastolic blood pressure significantly increased with ED compared to CD (peak change 7 ± 16 mmHg vs 1 ± 16 mmHg, 6% vs 0.8%, p = 0.046 and 8 ± 10 vs 2 ± 9 mmHg, 11% vs 3% p = 0.01 respectively). These changes correlated with significant increases in serum caffeine (14.6 ± 11.3 vs 0.5 ± 0.1 μmol/L, p < 0.001) and serum taurine (737 ± 199 vs -59 ± 22 μmol/L, p < 0.001). There were three patients with dangerous QTc prolongation of ≥50ms following energy drink consumption. Conclusion Caffeinated energy drinks have significant haemodynamic effects in patients with LQTS, especifically an acute increase in blood pressure. Since dangerous QTc prolongation was seen in some LQTS patients, we recommend caution in young patients with LQTS consuming energy drinks.
KW - energy drinks
KW - Long QT syndrome
UR - http://www.scopus.com/inward/record.url?scp=85011841075&partnerID=8YFLogxK
U2 - 10.1016/j.ijcard.2016.12.019
DO - 10.1016/j.ijcard.2016.12.019
M3 - Article
VL - 231
SP - 150
EP - 154
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
ER -