Cardiovascular Alterations and Multiorgan Dysfunction After Birth Asphyxia

Graeme R. Polglase, Tracey Ong, Noah H Hillman

Research output: Contribution to journalReview ArticleOtherpeer-review

26 Citations (Scopus)


The cardiovascular response to asphyxia involves redistribution of cardiac output to maintain oxygen delivery to critical organs such as the adrenal gland, heart, and brain, at the expense of other organs such as the gut, kidneys and skin. This redistribution results in reduced perfusion and localized hypoxia/ischemia in these organs, which, if severe, can result in multiorgan failure. Liver injury, coagulopathy, bleeding, thrombocytopenia, renal dysfunction, and pulmonary and gastrointestinal injury all result from hypoxia, underperfusion, or both. Current clinical therapies need to be considered together with therapeutic hypothermia and cardiovascular recovery.

Original languageEnglish
Pages (from-to)469-483
Number of pages15
JournalClinics in Perinatology
Issue number3
Publication statusPublished - 1 Sep 2016
Externally publishedYes


  • Asphyxia
  • Cardiovascular
  • Kidneys
  • Liver
  • Multiorgan failure

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