Cardiopulmonary xenotransplantation: The past, the present and future prospects

Julian A. Smith, Bruce R. Rosengard, John Wallwork

Research output: Contribution to journalReview ArticleResearchpeer-review


The shortage of donor organs for heart and lung transplantation has stimulated a resurgence of interest in xenotransplantation from other species to humans. Experimental studies in many centres worldwide are using a variety of models in an effort to discover ways of overcoming the major obstacle to successful xenotransplantation, xenograft rejection. The clinical experience with solid organ xenotransplantation began 30 years ago and has been sporadic. An account of the immunological basis of xenograft rejection is presented herein followed by an overview of approaches under study to overcome rejection. We conclude that at present there are insufficient scientific data on which to base clinical cardiopulmonary xenotransplantation.

Original languageEnglish
Pages (from-to)8-16
Number of pages9
JournalAsia Pacific Journal of Thoracic and Cardiovascular Surgery
Issue number1
Publication statusPublished - 1 Jan 1995
Externally publishedYes

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