Cardiac troponin detection using silicon photonic biosensor for the accurate and timely diagnosis and prognosis of acute myocardial infarction

Siew Joo Beh, Markus Knoerzer, Crispin Szydzik, Guanghui Ren, César Sanchez Huertas, Arnan Mitchell

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

Abstract

We report a silicon Mach-Zehnder interferometer biosensor with an integrated microfluidic sample handling for an accurate and timely detection of cardiac troponin. The performance of the photonic biosensor was evaluated in terms of sensitivity, selectivity and reproducibility following the international clinical guidelines for acute myocardial infarction with the obtention of a complete cardiac troponin point-of-care test. We demonstrated that this biosensor was able to selectively detect cardiac troponin within 10 minutes in the ng/mL-μg/mL range with high reproducibility, achieving a limit of detection as low as 3 ng/mL in a direct assay.

Original languageEnglish
Title of host publicationBiophotonics Australasia 2019
EditorsEwa M. Goldys, Brant C. Gibson
Place of PublicationBellingham WA USA
PublisherSPIE - International Society for Optical Engineering
Number of pages2
ISBN (Electronic)9781510631441
DOIs
Publication statusPublished - 30 Dec 2019
EventSPIE Biophotonics Australasia 2019 - Melbourne, Australia
Duration: 9 Dec 201912 Dec 2019

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume11202
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceSPIE Biophotonics Australasia 2019
CountryAustralia
CityMelbourne
Period9/12/1912/12/19

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