Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF

John F. O'Sullivan; Mengbo Li; Yen Chin Koay; Xiao Suo Wang; Giovanni Guglielmi; Francine Z. Marques; Shane Nanayakkara; Justin Mariani; Eugene Slaughter; David M. Kaye

doi:10.1016/j.jacbts.2023.11.006

Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF

John F. O'Sullivan, Mengbo Li, Yen Chin Koay, Xiao Suo Wang, Giovanni Guglielmi, Francine Z. Marques, Shane Nanayakkara, Justin Mariani, Eugene Slaughter, David M. Kaye

Research output: Contribution to journal › Article › Research › peer-review

7 Citations (Scopus)

Abstract

The authors conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified.

Original language	English
Pages (from-to)	281-299
Number of pages	19
Journal	JACC: Basic to Translational Science
Volume	9
Issue number	3
DOIs	https://doi.org/10.1016/j.jacbts.2023.11.006
Publication status	Published - Mar 2024

Keywords

cardiac energetics
heart failure with preserved ejection fraction
invasive hemodynamics
lipids

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10.1016/j.jacbts.2023.11.006Licence: CC BY-NC-ND

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title = "Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF",

abstract = "The authors conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified.",

keywords = "cardiac energetics, heart failure with preserved ejection fraction, invasive hemodynamics, lipids",

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doi = "10.1016/j.jacbts.2023.11.006",

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AU - O'Sullivan, John F.

AU - Li, Mengbo

AU - Koay, Yen Chin

AU - Wang, Xiao Suo

AU - Guglielmi, Giovanni

AU - Marques, Francine Z.

AU - Nanayakkara, Shane

AU - Mariani, Justin

AU - Slaughter, Eugene

AU - Kaye, David M.

PY - 2024/3

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AB - The authors conducted transcardiac blood sampling in healthy subjects and subjects with heart failure with preserved ejection fraction (HFpEF) to compare cardiac metabolite and lipid substrate use. We demonstrate that fatty acids are less used by HFpEF hearts and that lipid extraction is influenced by hemodynamic factors including pulmonary pressures and cardiac index. The release of many products of protein catabolism is apparent in HFpEF compared to healthy myocardium. In subgroup analyses, differences in energy substrate use between female and male hearts were identified.

KW - cardiac energetics

KW - heart failure with preserved ejection fraction

KW - invasive hemodynamics

KW - lipids

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Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF

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Keywords

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Cardiac Substrate Utilization and Relationship to Invasive Exercise Hemodynamic Parameters in HFpEF

Abstract

Keywords

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Targeting the gut microbiota to treat cardiovascular disease

Targeting the gut microbiota to prevent and treat cardiovascular disease

High blood pressure and gut microbiota: mechanisms and therapeutic potential

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