Cardiac gene delivery using recirculating devices

Melissa J. Byrne, David M. Kaye

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Abstract

Cardiac gene delivery has become an important issue following the emergence of gene therapy for the possible treatment of heart failure. Despite many advances in the management of heart failure (HF), treatment options for many patients with advanced HF remain limited. At a cellular and molecular level, many of the fundamental alterations that contribute to the pathogenesis of HF are becoming better understood and this has resulted in the discovery of new therapeutic targets in animal models of HF, in particular in the area of gene therapy. Numerous small animal and preclinical studies have examined the efficacy of delivering genes targeting various signaling pathways that are affected as the heart fails. However, the translation of this work into the clinic has been difficult due to the requirement for large scale targeted delivery of the gene. This methods chapter describes a percutaneous method of recirculation that we have employed to successfully deliver potential therapeutic agents, including genes, to the heart.

Original languageEnglish
Title of host publicationCardiac Gene Therapy
Subtitle of host publicationMethods and Protocols
EditorsKiyotake Ishikawa
Place of PublicationNew York, NY
PublisherHumana Press
Chapter19
Pages261-269
Number of pages9
ISBN (Electronic)9781493965885
ISBN (Print) 9781493965861
DOIs
Publication statusPublished - 2017
Externally publishedYes

Publication series

NameMethods in Molecular Biology
Volume1521
ISSN (Print)10643745
ISSN (Electronic)1940-6029

Keywords

  • Cardiac
  • Gene delivery
  • Percutaneous
  • Recirculation
  • Targeted

Cite this

Byrne, M. J., & Kaye, D. M. (2017). Cardiac gene delivery using recirculating devices. In K. Ishikawa (Ed.), Cardiac Gene Therapy : Methods and Protocols (pp. 261-269). (Methods in Molecular Biology; Vol. 1521). Humana Press. https://doi.org/10.1007/978-1-4939-6588-5_19