Cardiac effects of relaxin in rats

H. Kakouris; L. W. Eddie; R. J. Summers

doi:10.1016/0140-6736(92)90665-P

Cardiac effects of relaxin in rats

H. Kakouris, L. W. Eddie, R. J. Summers

Drug Discovery Biology

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106 Citations (Scopus)

Abstract

Relaxin is usually considered to be a hormone of pregnancy, but porcine relaxin has been shown to increase heart rate in rats. We investigated the cardiac effects of synthetic human gene-2 relaxin (hRlx-2) in vitro in isolated rat atria. Synthetic hRlx-2 produced concentration-dependent positive chronotropic effects in spontaneously beating right atria (EC₅₀ [concentration required to produce 50% of the maximal response] =0·09 [SE 0·03] nmol/l) and concentration-dependent positive inotropic effects in electrically driven left atria (EC₅₀=0·31 [0·02] nmol/l). The potency of hRlx-2 is greater than that of endothelin, angiotensin II, and (-)-isoprenaline in isolated rat atria. Relaxin has powerful chronotropic and inotropic effects on the heart that are probably mediated through a direct action on relaxin receptors. Lancet 1992; 339: 1076-78.

Original language	English
Pages (from-to)	1076-1078
Number of pages	3
Journal	The Lancet
Volume	339
Issue number	8801
DOIs	https://doi.org/10.1016/0140-6736(92)90665-P
Publication status	Published - 2 May 1992

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title = "Cardiac effects of relaxin in rats",

abstract = "Relaxin is usually considered to be a hormone of pregnancy, but porcine relaxin has been shown to increase heart rate in rats. We investigated the cardiac effects of synthetic human gene-2 relaxin (hRlx-2) in vitro in isolated rat atria. Synthetic hRlx-2 produced concentration-dependent positive chronotropic effects in spontaneously beating right atria (EC50 [concentration required to produce 50% of the maximal response] =0·09 [SE 0·03] nmol/l) and concentration-dependent positive inotropic effects in electrically driven left atria (EC50=0·31 [0·02] nmol/l). The potency of hRlx-2 is greater than that of endothelin, angiotensin II, and (-)-isoprenaline in isolated rat atria. Relaxin has powerful chronotropic and inotropic effects on the heart that are probably mediated through a direct action on relaxin receptors. Lancet 1992; 339: 1076-78.",

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T1 - Cardiac effects of relaxin in rats

AU - Kakouris, H.

AU - Eddie, L. W.

AU - Summers, R. J.

PY - 1992/5/2

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N2 - Relaxin is usually considered to be a hormone of pregnancy, but porcine relaxin has been shown to increase heart rate in rats. We investigated the cardiac effects of synthetic human gene-2 relaxin (hRlx-2) in vitro in isolated rat atria. Synthetic hRlx-2 produced concentration-dependent positive chronotropic effects in spontaneously beating right atria (EC50 [concentration required to produce 50% of the maximal response] =0·09 [SE 0·03] nmol/l) and concentration-dependent positive inotropic effects in electrically driven left atria (EC50=0·31 [0·02] nmol/l). The potency of hRlx-2 is greater than that of endothelin, angiotensin II, and (-)-isoprenaline in isolated rat atria. Relaxin has powerful chronotropic and inotropic effects on the heart that are probably mediated through a direct action on relaxin receptors. Lancet 1992; 339: 1076-78.

AB - Relaxin is usually considered to be a hormone of pregnancy, but porcine relaxin has been shown to increase heart rate in rats. We investigated the cardiac effects of synthetic human gene-2 relaxin (hRlx-2) in vitro in isolated rat atria. Synthetic hRlx-2 produced concentration-dependent positive chronotropic effects in spontaneously beating right atria (EC50 [concentration required to produce 50% of the maximal response] =0·09 [SE 0·03] nmol/l) and concentration-dependent positive inotropic effects in electrically driven left atria (EC50=0·31 [0·02] nmol/l). The potency of hRlx-2 is greater than that of endothelin, angiotensin II, and (-)-isoprenaline in isolated rat atria. Relaxin has powerful chronotropic and inotropic effects on the heart that are probably mediated through a direct action on relaxin receptors. Lancet 1992; 339: 1076-78.

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JO - The Lancet

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ER -

Cardiac effects of relaxin in rats

Abstract

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