Cardiac alternans suppression under T ± ε feedback control: nonlinear dynamics analysis

Shiuan Ni Liang, Duy Manh Le, Pik Yin Lai

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The nonlinear dynamical properties of the recently proposed T ± feedback control for suppressing cardiac alternans is investigated in detail for the discrete cardiac restitution map model and the continuous Luo-Rudy I ionic model. It is shown that cardiac alternans, induced by fast pacing, can be dramatically reduced by small changes of fixed magnitude () under feedback control when exceeds a critical threshold. Remarkably, the suppression is achieved by utilizing the induced chaotic dynamics. Detailed information on the nature and mechanism of the control, and properties of the attractors are analyzed and discussed in the light of nonlinear dynamics.

Original languageEnglish
Article number1930036
Number of pages15
JournalInternational Journal of Bifurcation and Chaos in Applied Sciences and Engineering
Issue number13
Publication statusPublished - 15 Dec 2019


  • application of chaos
  • cardiac dynamics
  • feedback control
  • Nonlinear dynamics and chaos

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