Carboxymethyl sago pulp/carboxymethyl sago starch hydrogel: Effect of polymer mixing ratio and study of controlled drug release

Hui Li Tan, Yeon Yin Wong, Saravanan Muniyandy, Kamaruddin Hashim, Janarthanan Pushpamalar

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11 Citations (Scopus)

Abstract

Carboxymethyl sag o pulp (CMSP)/carboxymethyl sago starch (CMSS) hydrogel was synthesized by electron beam irradiation. In the series of hydrogels prepared, 40%/20% CMSP/CMSS hydrogel had the highest gel fraction. The swelling capacity of CMSP/CMSS hydrogel was found to be highest in distilled water, followed by pH 11, pH 7.4, and pH 1.2. Scanning Electron Microscope photographs revealed that the drug-loaded hydrogel had a smoother surface than unloaded hydrogel. Fourier Transform Infrared and Differential Scanning Calorimetry analysis showed the absence of interaction between the hydrogels and the drug. All drug-loaded hydrogels had drug encapsulation efficiency between 63% and 69%. CMSP/CMSS hydrogel swelled and allowed the release of drug at pH 7.4. These properties qualify the hydrogel as a potential candidate for controlled drug release at the ocular and colonic regions.

Original languageEnglish
Article number43652
Number of pages13
JournalJournal of Applied Polymer Science
Volume133
Issue number28
DOIs
Publication statusPublished - 20 Jul 2016

Keywords

  • biodegradable
  • biopolymers & renewable polymers
  • cross-linking
  • drug delivery systems
  • irradiation

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