Carbon-carbon bond cleavage by cytochrome P450Biol (CYP107H1)

Max J. Cryle, James J. De Voss

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Cytochrome P450Biol (CYP107H1) is believed to supply pimelic acid equivalents for biotin biosynthesis in Bacillus subtilis: we report here that the mechanistic pathway adopted by this multifunctional P450 for the in-chain cleavage of fatty acids is via consecutive formation of alcohol and threo-diol intermediates, with the likely absolute configuration of the intermediates also reported.

Original languageEnglish
Pages (from-to)86-87
Number of pages2
JournalChemical Communications
Issue number1
Publication statusPublished - 7 Jan 2004
Externally publishedYes

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