Carbohydrates@MOFs

Efwita Astria, Martin Thonhofer, Raffaele Ricco, Weibin Liang, Angela Chemelli, Andrew Tarzia, Karen Alt, Christoph E. Hagemeyer, Johannes Rattenberger, Hartmuth Schroettner, Tanja Wrodnigg, Heinz Amenitsch, David M. Huang, Christian J. Doonan, Paolo Falcaro

Research output: Contribution to journalArticleResearchpeer-review

Abstract

MOFs have demonstrated outstanding properties for the protection and controlled release of different bio-entities, from proteins to living cells. Carbohydrates, as pure molecules or as a component of proteins and cells, perform essential biological functions. Thus, an understanding of the role of carbohydrates in the formation of MOF-based bio-composites will facilitate their application to biotechnology and medicine. Here, we investigate the role of carbohydrate molecular weight and chemical functionalization in the formation of carbohydrate@MOF composites. We find that chemical functionalization, such as carboxylation, that leads to an enhancement of metal cation concentration at the surface of the molecule triggers the rapid self-assembly of the MOF material, zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determine the encapsulation efficiency and measure the release properties of the carbohydrate under controlled conditions. Our findings show that MOFs can be used to prepare a new class of biocomposites for the delivery of carbohydrate-based therapeutics.

Original languageEnglish
Pages (from-to)969-977
Number of pages9
JournalMaterials Horizons
Volume6
Issue number5
DOIs
Publication statusPublished - 1 Jun 2019

Cite this

Astria, E., Thonhofer, M., Ricco, R., Liang, W., Chemelli, A., Tarzia, A., ... Falcaro, P. (2019). Carbohydrates@MOFs. Materials Horizons, 6(5), 969-977. https://doi.org/10.1039/c8mh01611a
Astria, Efwita ; Thonhofer, Martin ; Ricco, Raffaele ; Liang, Weibin ; Chemelli, Angela ; Tarzia, Andrew ; Alt, Karen ; Hagemeyer, Christoph E. ; Rattenberger, Johannes ; Schroettner, Hartmuth ; Wrodnigg, Tanja ; Amenitsch, Heinz ; Huang, David M. ; Doonan, Christian J. ; Falcaro, Paolo. / Carbohydrates@MOFs. In: Materials Horizons. 2019 ; Vol. 6, No. 5. pp. 969-977.
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title = "Carbohydrates@MOFs",
abstract = "MOFs have demonstrated outstanding properties for the protection and controlled release of different bio-entities, from proteins to living cells. Carbohydrates, as pure molecules or as a component of proteins and cells, perform essential biological functions. Thus, an understanding of the role of carbohydrates in the formation of MOF-based bio-composites will facilitate their application to biotechnology and medicine. Here, we investigate the role of carbohydrate molecular weight and chemical functionalization in the formation of carbohydrate@MOF composites. We find that chemical functionalization, such as carboxylation, that leads to an enhancement of metal cation concentration at the surface of the molecule triggers the rapid self-assembly of the MOF material, zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determine the encapsulation efficiency and measure the release properties of the carbohydrate under controlled conditions. Our findings show that MOFs can be used to prepare a new class of biocomposites for the delivery of carbohydrate-based therapeutics.",
author = "Efwita Astria and Martin Thonhofer and Raffaele Ricco and Weibin Liang and Angela Chemelli and Andrew Tarzia and Karen Alt and Hagemeyer, {Christoph E.} and Johannes Rattenberger and Hartmuth Schroettner and Tanja Wrodnigg and Heinz Amenitsch and Huang, {David M.} and Doonan, {Christian J.} and Paolo Falcaro",
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Astria, E, Thonhofer, M, Ricco, R, Liang, W, Chemelli, A, Tarzia, A, Alt, K, Hagemeyer, CE, Rattenberger, J, Schroettner, H, Wrodnigg, T, Amenitsch, H, Huang, DM, Doonan, CJ & Falcaro, P 2019, 'Carbohydrates@MOFs', Materials Horizons, vol. 6, no. 5, pp. 969-977. https://doi.org/10.1039/c8mh01611a

Carbohydrates@MOFs. / Astria, Efwita; Thonhofer, Martin; Ricco, Raffaele; Liang, Weibin; Chemelli, Angela; Tarzia, Andrew; Alt, Karen; Hagemeyer, Christoph E.; Rattenberger, Johannes; Schroettner, Hartmuth; Wrodnigg, Tanja; Amenitsch, Heinz; Huang, David M.; Doonan, Christian J.; Falcaro, Paolo.

In: Materials Horizons, Vol. 6, No. 5, 01.06.2019, p. 969-977.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Carbohydrates@MOFs

AU - Astria, Efwita

AU - Thonhofer, Martin

AU - Ricco, Raffaele

AU - Liang, Weibin

AU - Chemelli, Angela

AU - Tarzia, Andrew

AU - Alt, Karen

AU - Hagemeyer, Christoph E.

AU - Rattenberger, Johannes

AU - Schroettner, Hartmuth

AU - Wrodnigg, Tanja

AU - Amenitsch, Heinz

AU - Huang, David M.

AU - Doonan, Christian J.

AU - Falcaro, Paolo

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Y1 - 2019/6/1

N2 - MOFs have demonstrated outstanding properties for the protection and controlled release of different bio-entities, from proteins to living cells. Carbohydrates, as pure molecules or as a component of proteins and cells, perform essential biological functions. Thus, an understanding of the role of carbohydrates in the formation of MOF-based bio-composites will facilitate their application to biotechnology and medicine. Here, we investigate the role of carbohydrate molecular weight and chemical functionalization in the formation of carbohydrate@MOF composites. We find that chemical functionalization, such as carboxylation, that leads to an enhancement of metal cation concentration at the surface of the molecule triggers the rapid self-assembly of the MOF material, zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determine the encapsulation efficiency and measure the release properties of the carbohydrate under controlled conditions. Our findings show that MOFs can be used to prepare a new class of biocomposites for the delivery of carbohydrate-based therapeutics.

AB - MOFs have demonstrated outstanding properties for the protection and controlled release of different bio-entities, from proteins to living cells. Carbohydrates, as pure molecules or as a component of proteins and cells, perform essential biological functions. Thus, an understanding of the role of carbohydrates in the formation of MOF-based bio-composites will facilitate their application to biotechnology and medicine. Here, we investigate the role of carbohydrate molecular weight and chemical functionalization in the formation of carbohydrate@MOF composites. We find that chemical functionalization, such as carboxylation, that leads to an enhancement of metal cation concentration at the surface of the molecule triggers the rapid self-assembly of the MOF material, zeolitic-imidazolate framework 8 (ZIF-8). Furthermore, we determine the encapsulation efficiency and measure the release properties of the carbohydrate under controlled conditions. Our findings show that MOFs can be used to prepare a new class of biocomposites for the delivery of carbohydrate-based therapeutics.

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DO - 10.1039/c8mh01611a

M3 - Article

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JO - Materials Horizons

JF - Materials Horizons

SN - 2051-6347

IS - 5

ER -

Astria E, Thonhofer M, Ricco R, Liang W, Chemelli A, Tarzia A et al. Carbohydrates@MOFs. Materials Horizons. 2019 Jun 1;6(5):969-977. https://doi.org/10.1039/c8mh01611a