Carbohydrate-based scaffolds in drug discovery

Bernd Becker; Glenn C. Condie; Giang Thanh Le; Wim Meutermans

doi:10.2174/138955706778993003

Carbohydrate-based scaffolds in drug discovery

Bernd Becker, Glenn C. Condie, Giang Thanh Le, Wim Meutermans

Research output: Contribution to journal › Article › Research › peer-review

23 Citations (Scopus)

Abstract

Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.

Original language	English
Pages (from-to)	1299-1309
Number of pages	11
Journal	Mini-Reviews in Medicinal Chemistry
Volume	6
Issue number	12
DOIs	https://doi.org/10.2174/138955706778993003
Publication status	Published - 1 Dec 2006
Externally published	Yes

Keywords

Carbohydrate scaffolds
Carbohydrates
Combinatorial chemistry
Mimetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2174/138955706778993003

Cite this

@article{1570130ad935400ebb964a9f7fae28cd,

title = "Carbohydrate-based scaffolds in drug discovery",

abstract = "Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.",

keywords = "Carbohydrate scaffolds, Carbohydrates, Combinatorial chemistry, Mimetics",

author = "Bernd Becker and Condie, {Glenn C.} and Le, {Giang Thanh} and Wim Meutermans",

year = "2006",

month = dec,

day = "1",

doi = "10.2174/138955706778993003",

language = "English",

volume = "6",

pages = "1299--1309",

journal = "Mini-Reviews in Medicinal Chemistry",

issn = "1389-5575",

publisher = "Bentham Science Publishers",

number = "12",

}

TY - JOUR

T1 - Carbohydrate-based scaffolds in drug discovery

AU - Becker, Bernd

AU - Condie, Glenn C.

AU - Le, Giang Thanh

AU - Meutermans, Wim

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.

AB - Carbohydrates have been proven as valuable scaffolds to display pharmocophores and the resulting molecules have demonstrated useful biological activity towards various targets including the somatostatin receptors (SSTR), integrins, HIV-1 protease, matrix metalloproteinases (MMP), multidrug resistance-associated protein (MRP), and as RNA binders. Carbohydrate-based compounds have also shown antibacterial and herbicidal activity.

KW - Carbohydrate scaffolds

KW - Carbohydrates

KW - Combinatorial chemistry

KW - Mimetics

UR - http://www.scopus.com/inward/record.url?scp=33845429218&partnerID=8YFLogxK

U2 - 10.2174/138955706778993003

DO - 10.2174/138955706778993003

M3 - Article

C2 - 17168806

AN - SCOPUS:33845429218

SN - 1389-5575

VL - 6

SP - 1299

EP - 1309

JO - Mini-Reviews in Medicinal Chemistry

JF - Mini-Reviews in Medicinal Chemistry

IS - 12

ER -

Carbohydrate-based scaffolds in drug discovery

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Cite this