CAR-T cells are serial killers

Alexander J Davenport; Misty R. Jenkins; David S Ritchie; H. Miles Prince; Joseph A. Trapani; Michael H. Kershaw; Phillip K. Darcy; Paul J. Neeson

doi:10.1080/2162402X.2015.1053684

CAR-T cells are serial killers

Alexander J Davenport
, Misty R. Jenkins
, David S Ritchie
, H. Miles Prince
, Joseph A. Trapani
, Michael H. Kershaw
, Phillip K. Darcy
, Paul J. Neeson

Research output: Contribution to journal › Article › Other › peer-review

17 Citations (Scopus)

Abstract

Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20 hours.

Original language	English
Journal	OncoImmunology
Volume	4
Issue number	12
DOIs	https://doi.org/10.1080/2162402X.2015.1053684
Publication status	Published - 2 Dec 2015
Externally published	Yes

Keywords

CAR
serial killing
T cell therapy

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10.1080/2162402X.2015.1053684

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title = "CAR-T cells are serial killers",

abstract = "Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20 hours.",

keywords = "CAR, serial killing, T cell therapy",

author = "Davenport, \{Alexander J\} and Jenkins, \{Misty R.\} and Ritchie, \{David S\} and Prince, \{H. Miles\} and Trapani, \{Joseph A.\} and Kershaw, \{Michael H.\} and Darcy, \{Phillip K.\} and Neeson, \{Paul J.\}",

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doi = "10.1080/2162402X.2015.1053684",

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AU - Davenport, Alexander J

AU - Jenkins, Misty R.

AU - Ritchie, David S

AU - Prince, H. Miles

AU - Trapani, Joseph A.

AU - Kershaw, Michael H.

AU - Darcy, Phillip K.

AU - Neeson, Paul J.

PY - 2015/12/2

Y1 - 2015/12/2

N2 - Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20 hours.

AB - Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20 hours.

KW - CAR

KW - serial killing

KW - T cell therapy

UR - https://www.scopus.com/pages/publications/84944629935

U2 - 10.1080/2162402X.2015.1053684

DO - 10.1080/2162402X.2015.1053684

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VL - 4

JO - OncoImmunology

JF - OncoImmunology

IS - 12

ER -

CAR-T cells are serial killers

Abstract

Keywords

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