Capturing the Structure of the Substrate Bound Condensation Domain

Tiia Kittila, Max J. Cryle

Research output: Contribution to journalEditorialOtherpeer-review


Condensation domains of nonribosomal peptide synthetase machineries have so far escaped detailed structural analysis. In this issue of Cell Chemical Biology, Bloudoff et al. (2016) describe a protein tethering technique that allowed the authors to obtain structural information on the substrate bound state of the first condensation domain from calcium-dependent antibiotic biosynthesis, thus opening a new window into how these important biosynthetic machineries function.
Original languageEnglish
Pages (from-to)315-316
Number of pages2
JournalChemistry and Biology
Issue number3
Publication statusPublished - 17 Mar 2016

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