Cancer stem cell targeted therapy: progress amid controversies

Tao Wang; Sarah L Shigdar; Michael Paul Marie Gantier; Yingchun Hou; Li Wang; Yong Li; Hadi Al Shamaileh; Wang Yin; Shu-Feng Zhou; Xinhan Zhao; Wei Duan

doi:10.18632/oncotarget.6176

Cancer stem cell targeted therapy: progress amid controversies

Tao Wang, Sarah L Shigdar, Michael Paul Marie Gantier, Yingchun Hou, Li Wang, Yong Li, Hadi Al Shamaileh, Wang Yin, Shu-Feng Zhou, Xinhan Zhao, Wei Duan

Hudson Institute - Department of Molecular and Translational Science

Research output: Contribution to journal › Article › Research › peer-review

119 Citations (Scopus)

Abstract

Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.

Original language	English
Pages (from-to)	44191 - 44206
Number of pages	16
Journal	Oncotarget
Volume	6
Issue number	42
DOIs	https://doi.org/10.18632/oncotarget.6176
Publication status	Published - 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.18632/oncotarget.6176Licence: CC BY

3577229-oaFinal published version, 3.3 MBLicence: CC BY

Cite this

@article{44aa1145d34b403db570456c73e15e1e,

title = "Cancer stem cell targeted therapy: progress amid controversies",

abstract = "Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.",

author = "Tao Wang and Shigdar, {Sarah L} and Gantier, {Michael Paul Marie} and Yingchun Hou and Li Wang and Yong Li and {Al Shamaileh}, Hadi and Wang Yin and Shu-Feng Zhou and Xinhan Zhao and Wei Duan",

year = "2015",

doi = "10.18632/oncotarget.6176",

language = "English",

volume = "6",

pages = "44191 -- 44206",

journal = "Oncotarget",

issn = "1949-2553",

publisher = "Impact Journals, LLC",

number = "42",

}

TY - JOUR

T1 - Cancer stem cell targeted therapy: progress amid controversies

AU - Wang, Tao

AU - Shigdar, Sarah L

AU - Gantier, Michael Paul Marie

AU - Hou, Yingchun

AU - Wang, Li

AU - Li, Yong

AU - Al Shamaileh, Hadi

AU - Yin, Wang

AU - Zhou, Shu-Feng

AU - Zhao, Xinhan

AU - Duan, Wei

PY - 2015

Y1 - 2015

N2 - Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.

AB - Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.

UR - http://www.ncbi.nlm.nih.gov/pubmed/26496035

U2 - 10.18632/oncotarget.6176

DO - 10.18632/oncotarget.6176

M3 - Article

VL - 6

SP - 44191

EP - 44206

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 42

ER -

Cancer stem cell targeted therapy: progress amid controversies

Abstract

UN SDGs

Access to Document

Other files and links

Cite this