Cancer stem cell targeted therapy: progress amid controversies

Tao Wang, Sarah L Shigdar, Michael Paul Marie Gantier, Yingchun Hou, Li Wang, Yong Li, Hadi Al Shamaileh, Wang Yin, Shu-Feng Zhou, Xinhan Zhao, Wei Duan

Research output: Contribution to journalArticleResearchpeer-review

102 Citations (Scopus)

Abstract

Although cancer stem cells have been well characterized in numerous malignancies, the fundamental characteristics of this group of cells, however, have been challenged by some recent observations: cancer stem cells may not necessary to be rare within tumors; cancer stem cells and non-cancer stem cells may undergo reversible phenotypic changes; and the cancer stem cells phenotype can vary substantially between patients. Here the current status and progresses of cancer stem cells theory is illustrated and via providing a panoramic view of cancer therapy, we addressed the recent controversies regarding the feasibility of cancer stem cells targeted anti-cancer therapy.
Original languageEnglish
Pages (from-to)44191 - 44206
Number of pages16
JournalOncotarget
Volume6
Issue number42
DOIs
Publication statusPublished - 2015

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