TY - JOUR
T1 - Cancer neuroscience
T2 - State of the field, emerging directions
AU - Winkler, Frank
AU - Venkatesh, Humsa S.
AU - Amit, Moran
AU - Batchelor, Tracy
AU - Demir, Ihsan Ekin
AU - Deneen, Benjamin
AU - Gutmann, David H.
AU - Hervey-Jumper, Shawn
AU - Kuner, Thomas
AU - Mabbott, Donald
AU - Platten, Michael
AU - Rolls, Asya
AU - Sloan, Erica K.
AU - Wang, Timothy C.
AU - Wick, Wolfgang
AU - Venkataramani, Varun
AU - Monje, Michelle
N1 - Funding Information:
This review article derives from and is written by the participants of a Cancer Neuroscience Think Tank meeting held jointly between the Cancer Neuroscience Programs of Heidelberg University, Stanford University, and Harvard Medical School on July 18–19, 2022. The authors acknowledge Yvonne Yang for help with Figure 3 design. Initial drafts of figures were made with BioRender.com. The authors are grateful for support from the US National Institutes of Health (DP1NS111132, R01NS092597, P50CA165962, R01CA258384, R01CA261939, R35NS097211, R01DE032018, R37CA242006, U19CA264504), Deutsche Forschungsgemeinschaft (SFB 1389, UNITE Glioblastoma, project ID 404521405, and VE1373/2-1), Else Kroener-Fresenius-Stiftung (2020-EKEA.135), Virginia and D.K. Ludwig Fund for Cancer Research, ChadTough Defeat DIPG Foundation, Alex's Lemonade Stand Foundation, The University of Texas, MD Anderson Cancer SPORE in Melanoma (P50-CA093459), the Jim Mulva Foundation, and the Sontag Foundation. M.M. F.W. V.V. and H.S.V. wrote the manuscript; M.M. F.W. and V.V. made the figures; all authors (F.W. H.S.V. M.A. T.B. I.E.D. B.D. D.H.G. S.H.J. T.K. D.M. M.P. A.R. E.K.S. T.C.W. W.W. V.V. and M.M.) edited the manuscript. M.M. holds equity in MapLight Therapeutics. M.M. and H.S.V. report the patent (US Patent #10,377,818) “Method for treating glioma.” F.W. and W.W. report the patent (WO2017020982A1) “Agents for use in the treatment of glioma.” F.W. is a co-founder of DC Europa Ltd (a company trading under the name Divide & Conquer) that is developing new medicines for the treatment of glioma. Divide & Conquer also provides research funding to F.W.’s lab under a research collaboration agreement.
Funding Information:
This review article derives from and is written by the participants of a Cancer Neuroscience Think Tank meeting held jointly between the Cancer Neuroscience Programs of Heidelberg University, Stanford University, and Harvard Medical School on July 18–19, 2022. The authors acknowledge Yvonne Yang for help with Figure 3 design. Initial drafts of figures were made with BioRender.com . The authors are grateful for support from the US National Institutes of Health ( DP1NS111132 , R01NS092597 , P50CA165962 , R01CA258384 , R01CA261939 , R35NS097211 , R01DE032018 , R37CA242006 , U19CA264504 ), Deutsche Forschungsgemeinschaft ( SFB 1389 , UNITE Glioblastoma, project ID 404521405, and VE1373/2-1), Else Kroener-Fresenius-Stiftung ( 2020-EKEA.135 ), Virginia and D.K. Ludwig Fund for Cancer Research , ChadTough Defeat DIPG Foundation , Alex's Lemonade Stand Foundation , The University of Texas, MD Anderson Cancer SPORE in Melanoma ( P50-CA093459 ), the Jim Mulva Foundation, and the Sontag Foundation .
Publisher Copyright:
© 2023 The Author(s)
PY - 2023/4/13
Y1 - 2023/4/13
N2 - The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.
AB - The nervous system governs both ontogeny and oncology. Regulating organogenesis during development, maintaining homeostasis, and promoting plasticity throughout life, the nervous system plays parallel roles in the regulation of cancers. Foundational discoveries have elucidated direct paracrine and electrochemical communication between neurons and cancer cells, as well as indirect interactions through neural effects on the immune system and stromal cells in the tumor microenvironment in a wide range of malignancies. Nervous system-cancer interactions can regulate oncogenesis, growth, invasion and metastatic spread, treatment resistance, stimulation of tumor-promoting inflammation, and impairment of anti-cancer immunity. Progress in cancer neuroscience may create an important new pillar of cancer therapy.
UR - http://www.scopus.com/inward/record.url?scp=85151566808&partnerID=8YFLogxK
U2 - 10.1016/j.cell.2023.02.002
DO - 10.1016/j.cell.2023.02.002
M3 - Review Article
C2 - 37059069
AN - SCOPUS:85151566808
SN - 0092-8674
VL - 186
SP - 1689
EP - 1707
JO - Cell
JF - Cell
IS - 8
ER -
