Cancer, immunodeficiency and antiretroviral treatment: results from the Australian HIV Observational Database (AHOD)

Kathy Petoumenos, M T van Leuwen, Claire M Vajdic, Ian John Woolley, John Chuah, David J Templeton, Andrew Grulich, Matthew G Law

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Abstract

Objectives: The objective of the study was to conduct a within-cohort assessment of risk factors for incident AIDS-defining cancers (ADCs) and non-ADCs (NADCs) within the Australian HIV Observational Database (AHOD). Methods: A total of 2181 AHOD registrants were linked to the National AIDS Registry/National HIV Database (NAR/NHD) and the Australian Cancer Registry to identify those with a notified cancer diagnosis. Included in the current analyses were cancers diagnosed after HIV infection. Risk factors for cancers were also assessed using logistic regression methods. Results: One hundred and thirty-nine cancer cases were diagnosed after HIV infection among 129 patients. More than half the diagnoses (n=68; 60 ) were ADCs, of which 69 were Kaposi s sarcoma and 31 non-Hodgkin s lymphoma. Among the NADCs, the most common cancers were melanoma (n=10), lung cancer (n=6), Hodgkin s lymphoma (n=5) and anal cancer (n=5). Over a total of 21021 person-years (PY) of follow-up since HIV diagnosis, the overall crude cancer incidence rate for any cancer was 5.09/1000 PY. The overall rate of cancers decreased from 15.9/1000 PY [95 confidence interval (CI) 9.25-25.40/1000 PY] for CD4 counts 350 cells/?L. Lower CD4 cell count and prior AIDS diagnoses were significant predictors for both ADCs and NADCs. Conclusions: ADCs remain the predominant cancers in this population, although NADC rates have increased in the more recent time period. Immune deficiency is a risk factor for both ADCs and NADCs
Original languageEnglish
Pages (from-to)77 - 84
Number of pages8
JournalHIV Medicine
Volume14
Issue number2
DOIs
Publication statusPublished - 2013

Cite this

Petoumenos, Kathy ; van Leuwen, M T ; Vajdic, Claire M ; Woolley, Ian John ; Chuah, John ; Templeton, David J ; Grulich, Andrew ; Law, Matthew G. / Cancer, immunodeficiency and antiretroviral treatment: results from the Australian HIV Observational Database (AHOD). In: HIV Medicine. 2013 ; Vol. 14, No. 2. pp. 77 - 84.
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title = "Cancer, immunodeficiency and antiretroviral treatment: results from the Australian HIV Observational Database (AHOD)",
abstract = "Objectives: The objective of the study was to conduct a within-cohort assessment of risk factors for incident AIDS-defining cancers (ADCs) and non-ADCs (NADCs) within the Australian HIV Observational Database (AHOD). Methods: A total of 2181 AHOD registrants were linked to the National AIDS Registry/National HIV Database (NAR/NHD) and the Australian Cancer Registry to identify those with a notified cancer diagnosis. Included in the current analyses were cancers diagnosed after HIV infection. Risk factors for cancers were also assessed using logistic regression methods. Results: One hundred and thirty-nine cancer cases were diagnosed after HIV infection among 129 patients. More than half the diagnoses (n=68; 60 ) were ADCs, of which 69 were Kaposi s sarcoma and 31 non-Hodgkin s lymphoma. Among the NADCs, the most common cancers were melanoma (n=10), lung cancer (n=6), Hodgkin s lymphoma (n=5) and anal cancer (n=5). Over a total of 21021 person-years (PY) of follow-up since HIV diagnosis, the overall crude cancer incidence rate for any cancer was 5.09/1000 PY. The overall rate of cancers decreased from 15.9/1000 PY [95 confidence interval (CI) 9.25-25.40/1000 PY] for CD4 counts 350 cells/?L. Lower CD4 cell count and prior AIDS diagnoses were significant predictors for both ADCs and NADCs. Conclusions: ADCs remain the predominant cancers in this population, although NADC rates have increased in the more recent time period. Immune deficiency is a risk factor for both ADCs and NADCs",
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Petoumenos, K, van Leuwen, MT, Vajdic, CM, Woolley, IJ, Chuah, J, Templeton, DJ, Grulich, A & Law, MG 2013, 'Cancer, immunodeficiency and antiretroviral treatment: results from the Australian HIV Observational Database (AHOD)', HIV Medicine, vol. 14, no. 2, pp. 77 - 84. https://doi.org/10.1111/j.1468-1293.2012.01038.x

Cancer, immunodeficiency and antiretroviral treatment: results from the Australian HIV Observational Database (AHOD). / Petoumenos, Kathy; van Leuwen, M T; Vajdic, Claire M; Woolley, Ian John; Chuah, John; Templeton, David J; Grulich, Andrew; Law, Matthew G.

In: HIV Medicine, Vol. 14, No. 2, 2013, p. 77 - 84.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Cancer, immunodeficiency and antiretroviral treatment: results from the Australian HIV Observational Database (AHOD)

AU - Petoumenos, Kathy

AU - van Leuwen, M T

AU - Vajdic, Claire M

AU - Woolley, Ian John

AU - Chuah, John

AU - Templeton, David J

AU - Grulich, Andrew

AU - Law, Matthew G

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N2 - Objectives: The objective of the study was to conduct a within-cohort assessment of risk factors for incident AIDS-defining cancers (ADCs) and non-ADCs (NADCs) within the Australian HIV Observational Database (AHOD). Methods: A total of 2181 AHOD registrants were linked to the National AIDS Registry/National HIV Database (NAR/NHD) and the Australian Cancer Registry to identify those with a notified cancer diagnosis. Included in the current analyses were cancers diagnosed after HIV infection. Risk factors for cancers were also assessed using logistic regression methods. Results: One hundred and thirty-nine cancer cases were diagnosed after HIV infection among 129 patients. More than half the diagnoses (n=68; 60 ) were ADCs, of which 69 were Kaposi s sarcoma and 31 non-Hodgkin s lymphoma. Among the NADCs, the most common cancers were melanoma (n=10), lung cancer (n=6), Hodgkin s lymphoma (n=5) and anal cancer (n=5). Over a total of 21021 person-years (PY) of follow-up since HIV diagnosis, the overall crude cancer incidence rate for any cancer was 5.09/1000 PY. The overall rate of cancers decreased from 15.9/1000 PY [95 confidence interval (CI) 9.25-25.40/1000 PY] for CD4 counts 350 cells/?L. Lower CD4 cell count and prior AIDS diagnoses were significant predictors for both ADCs and NADCs. Conclusions: ADCs remain the predominant cancers in this population, although NADC rates have increased in the more recent time period. Immune deficiency is a risk factor for both ADCs and NADCs

AB - Objectives: The objective of the study was to conduct a within-cohort assessment of risk factors for incident AIDS-defining cancers (ADCs) and non-ADCs (NADCs) within the Australian HIV Observational Database (AHOD). Methods: A total of 2181 AHOD registrants were linked to the National AIDS Registry/National HIV Database (NAR/NHD) and the Australian Cancer Registry to identify those with a notified cancer diagnosis. Included in the current analyses were cancers diagnosed after HIV infection. Risk factors for cancers were also assessed using logistic regression methods. Results: One hundred and thirty-nine cancer cases were diagnosed after HIV infection among 129 patients. More than half the diagnoses (n=68; 60 ) were ADCs, of which 69 were Kaposi s sarcoma and 31 non-Hodgkin s lymphoma. Among the NADCs, the most common cancers were melanoma (n=10), lung cancer (n=6), Hodgkin s lymphoma (n=5) and anal cancer (n=5). Over a total of 21021 person-years (PY) of follow-up since HIV diagnosis, the overall crude cancer incidence rate for any cancer was 5.09/1000 PY. The overall rate of cancers decreased from 15.9/1000 PY [95 confidence interval (CI) 9.25-25.40/1000 PY] for CD4 counts 350 cells/?L. Lower CD4 cell count and prior AIDS diagnoses were significant predictors for both ADCs and NADCs. Conclusions: ADCs remain the predominant cancers in this population, although NADC rates have increased in the more recent time period. Immune deficiency is a risk factor for both ADCs and NADCs

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