Can you reduce your AGE?. Strategies to prevent AGE accumulation in diabetes

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Advanced glycation end-products (AGEs) contribute to the development and progression of diabetic kidney disease. Several different strategies have been developed to prevent the accumulation of AGEs in experimental diabetes, many of which have proved highly effective in attenuating renal damage in experimental models, even the absence of blood glucose control. These data suggests that if AGEs can be directly treated, some of the complications of diabetes may also be prevented.

Original languageEnglish
Pages (from-to)85-92
Number of pages8
JournalDrug Discovery Today: Therapeutic Strategies
Volume4
Issue number1
DOIs
Publication statusPublished - 21 Dec 2007
Externally publishedYes

Cite this

@article{3c19ef8603a149bd816f6cf71d82f993,
title = "Can you reduce your AGE?. Strategies to prevent AGE accumulation in diabetes",
abstract = "Advanced glycation end-products (AGEs) contribute to the development and progression of diabetic kidney disease. Several different strategies have been developed to prevent the accumulation of AGEs in experimental diabetes, many of which have proved highly effective in attenuating renal damage in experimental models, even the absence of blood glucose control. These data suggests that if AGEs can be directly treated, some of the complications of diabetes may also be prevented.",
author = "Coughlan, {Melinda T.} and Cooper, {Mark E.} and Thomas, {Merlin C.}",
year = "2007",
month = "12",
day = "21",
doi = "10.1016/j.ddstr.2007.07.003",
language = "English",
volume = "4",
pages = "85--92",
journal = "Drug Discovery Today: Therapeutic Strategies",
issn = "1740-6773",
publisher = "Elsevier",
number = "1",

}

Can you reduce your AGE?. Strategies to prevent AGE accumulation in diabetes. / Coughlan, Melinda T.; Cooper, Mark E.; Thomas, Merlin C.

In: Drug Discovery Today: Therapeutic Strategies, Vol. 4, No. 1, 21.12.2007, p. 85-92.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Can you reduce your AGE?. Strategies to prevent AGE accumulation in diabetes

AU - Coughlan, Melinda T.

AU - Cooper, Mark E.

AU - Thomas, Merlin C.

PY - 2007/12/21

Y1 - 2007/12/21

N2 - Advanced glycation end-products (AGEs) contribute to the development and progression of diabetic kidney disease. Several different strategies have been developed to prevent the accumulation of AGEs in experimental diabetes, many of which have proved highly effective in attenuating renal damage in experimental models, even the absence of blood glucose control. These data suggests that if AGEs can be directly treated, some of the complications of diabetes may also be prevented.

AB - Advanced glycation end-products (AGEs) contribute to the development and progression of diabetic kidney disease. Several different strategies have been developed to prevent the accumulation of AGEs in experimental diabetes, many of which have proved highly effective in attenuating renal damage in experimental models, even the absence of blood glucose control. These data suggests that if AGEs can be directly treated, some of the complications of diabetes may also be prevented.

UR - http://www.scopus.com/inward/record.url?scp=37249051801&partnerID=8YFLogxK

U2 - 10.1016/j.ddstr.2007.07.003

DO - 10.1016/j.ddstr.2007.07.003

M3 - Review Article

VL - 4

SP - 85

EP - 92

JO - Drug Discovery Today: Therapeutic Strategies

JF - Drug Discovery Today: Therapeutic Strategies

SN - 1740-6773

IS - 1

ER -