Can tissue engineering concepts advance tumor biology research?

Dietmar W. Hutmacher, Daniela Loessner, Simone Rizzi, David L. Kaplan, David J. Mooney, Judith A. Clements

Research output: Contribution to journalReview ArticleResearchpeer-review

167 Citations (Scopus)

Abstract

Advances in tissue engineering have traditionally led to the design of scaffold-or matrix-based culture systems that better reflect the biological, physical and biochemical environment of the natural extracellular matrix. Although their clinical applications in regenerative medicine tend to receive most of the attention, it is obvious that other areas of biomedical research could be well served by the powerful tools that have already been developed in tissue engineering. In this article, we review the recent literature to demonstrate how tissue engineering platforms can enhance in vitro and in vivo models of tumorigenesis and thus hold great promise to contribute to future cancer research.

Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalTrends in Biotechnology
Volume28
Issue number3
DOIs
Publication statusPublished - Mar 2010
Externally publishedYes

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