Can pre-hospital administration reduce time to initial antibiotic therapy in septic patients?

Daniel Cudini, Karen Smith, Stephen Bernard, Michael Stephenson, Emily Andrew, Peter Cameron, Mark Lum, Andrew Udy, on behalf of the ARISE Investigators

Research output: Contribution to journalArticleResearchpeer-review

1 Citation (Scopus)


Objective: To quantify the potential time saved with pre-hospital antibiotic therapy in sepsis. Methods: Study data for adult patients transported by Ambulance Victoria (AV), and enrolled into the Australasian Resuscitation In Sepsis Evaluation (ARISE), were linked with pre-hospital electronic records. Results: An AV record was identified for 240 of 341 ARISE patients. The pre-hospital case notes referred to potential infection in 165 patients. The median time to first antibiotic administration from loading the patient into the ambulance was 107 (74–160) min. Conclusions: ARISE patients in Victoria were frequently identified pre-hospital. An opportunity exists to study the feasibility of pre-hospital antibiotic therapy.

Original languageEnglish
Pages (from-to)669-672
Number of pages4
JournalEmergency Medicine Australasia
Issue number4
Publication statusPublished - Aug 2019


  • antibiotics
  • out of hospital
  • pre-hospital
  • sepsis
  • sepsis management

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