Can natural products targeting EMT serve as the future anticancer therapeutics?

Sirajudheen Anwar, Jonaid Ahmad Malik, Sakeel Ahmed, Verma Abhishek Kameshwar, Jowaher Alanazi, Abdulwahab Alamri, Nafees Ahemad

Research output: Contribution to journalReview ArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Cancer is the leading cause of death and has remained a big challenge for the scientific community. Because of the growing concerns, new therapeutic regimens are highly demanded to decrease the global burden. Despite advancements in chemotherapy, drug resistance is still a major hurdle to successful treatment. The primary challenge should be identifying and developing appropriate therapeutics for cancer patients to improve their survival. Multiple pathways are dysregulated in cancers, including disturbance in cellular metabolism, cell cycle, apoptosis, or epigenetic alterations. Over the last two decades, natural products have been a major research interest due to their therapeutic potential in various ailments. Natural compounds seem to be an alternative option for cancer management. Natural substances derived from plants and marine sources have been shown to have anti-cancer activity in preclinical settings. They might be proved as a sword to kill cancerous cells. The present review attempted to consolidate the available information on natural compounds derived from plants and marine sources and their anti-cancer potential underlying EMT mechanisms.

Original languageEnglish
Article number7668
Number of pages20
JournalMolecules
Volume27
Issue number22
DOIs
Publication statusPublished - 2 Nov 2022

Keywords

  • anticancer therapy
  • cancer
  • cancer EMT
  • chemotherapy
  • epithelial-mesenchymal transition
  • natural chemical entities

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