Can mycophenolic acid dose requirement during the first transplant help predict dosing for the second transplant?

Vellaichamy M. Annapandian, Gopal Basu, Binu S. Mathew, Denise H. Fleming, Chakko K. Jacob, George T. John

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Abstract

We describe the pharmacokinetic profile of mycophenolic acid (MPA) in a patient receiving Mycophenolate mofetil (MMF) during her first and second renal transplantations. The MMF dose required to achieve a therapeutic range of MPA-AUC0-12h early following the second transplantation was 10 times greater than that required late following the first transplantation. Her MMF requirement then declined and continued to decrease even beyond 1 year. Intra-individual variability in MPA profiles precluded the ability to predict MMF dosing for the second transplant based on that during the first. Therapeutic drug monitoring of MMF should be continued beyond 1 year of transplantation.

Original languageEnglish
Pages (from-to)3449-3452
Number of pages4
JournalNephrology Dialysis Transplantation
Volume25
Issue number10
DOIs
Publication statusPublished - Oct 2010
Externally publishedYes

Keywords

  • intra-individual variability
  • mycophenolic acid
  • pharmacokinetics
  • renal transplantation
  • therapeutic drug monitoring

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