Can follicular helper T cells be targeted to improve vaccine efficacy?

Michelle A. Linterman, Danika L. Hill

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

The success of most vaccines relies on the generation of antibodies to provide protection against subsequent infection; this in turn depends on a robust germinal centre (GC) response that culminates in the production of long-lived antibody-secreting plasma cells. The size and quality of the GC response are directed by a specialised subset of CD4+ T cells: T follicular helper (Tfh) cells. Tfh cells provide growth and differentiation signals to GC B cells and mediate positive selection of high-affinity B cell clones in the GC, thereby determining which B cells exit the GC as plasma cells and memory B cells. Because of their central role in the production of long-lasting humoral immunity, Tfh cells represent an interesting target for rational vaccine design.

Original languageEnglish
Article number7388.1
JournalF1000Research
Volume5
DOIs
Publication statusPublished - 1 Jan 2016
Externally publishedYes

Cite this

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Can follicular helper T cells be targeted to improve vaccine efficacy? / Linterman, Michelle A.; Hill, Danika L.

In: F1000Research, Vol. 5, 7388.1, 01.01.2016.

Research output: Contribution to journalReview ArticleResearchpeer-review

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