Calcium in Cell-Extracellular Matrix Interactions

Sandeep Gopal, Hinke A.B. Multhaupt, John R. Couchman

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

22 Citations (Scopus)


In multicellular organisms, the cells are surrounded by persistent, dynamic extracellular matrix (ECM), the largest calcium reservoir in animals. ECM regulates several aspects of cell behavior including cell migration and adhesion, survival, gene expression and differentiation, thus playing a significant role in health and disease. Calcium is reported to be important in the assembly of ECM, where it binds to many ECM proteins. While serving as a calcium reservoir, ECM macromolecules can directly interact with cell surface receptors resulting in calcium transport across the membrane. This chapter mainly focusses on the role of cell-ECM interactions in cellular calcium regulation and how calcium itself mediates these interactions.

Original languageEnglish
Title of host publicationCalcium Signaling
EditorsMd. Shahidul Islam
Place of PublicationSwitzerland
Number of pages24
ISBN (Electronic)9783030124571
ISBN (Print)9783030124564
Publication statusPublished - 2020

Publication series

NameAdvances in Experimental Medicine and Biology
PublisherSpringer-Verlag London Ltd.
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019


  • Actin cytoskeleton
  • Calcium
  • Cell adhesion
  • Extracellular matrix
  • Focal adhesions
  • Integrins
  • Mechanosensing
  • Proteoglycans
  • Syndecans
  • TRP channels

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