Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system:Differences between peripheral and central CGRP receptor distribut

Jochen Lennerz, Victor Ruhle, Eugene Ceppa, Winfried Neuhuber, Nigel Bunnett, Eileen Grady, Karl Messlinger

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Abstract

CGRP meets its receptor in the rat dura mater. The CGRP receptor protein CLR (green) is expressed in smooth muscle cells (blue, SMA) in the media of meningeal arteries (left) but not in veins (right upper half). CLR is also found in trigeminal nerve bundles and mononuclear cells adjacent to the arteries. CGRP-receptor components are however not colocalized with axonal CGRP (red) in the dura, but expressed in Schwann cells (not visible at this magnification).
Original languageEnglish
Pages (from-to)1277 - 1299
Number of pages23
JournalThe Journal of Comparative Neurology
Volume507
Issue number3
DOIs
Publication statusPublished - 2008

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