Abstract
Caffeine is a widely used, legal psychoactive drug, commonly ingested during pregnancy in tea, coffee, cola, and energy drinks. Caffeine concentrations in the fetus are similar to maternal levels as caffeine readily crosses the placenta. This chapter reviews data indicating that fetal caffeine exposure during pregnancy can potentially affect brain development, predominantly through its ability to antagonize adenosine receptors. Most of the available data are derived from animal experimentation and there are little data concerning the neurodevelopmental effects of caffeine in humans. The findings of experimental studies are often conflicting due to differences in species, the degree of caffeine exposure, developmental stage of the brain at exposure, age at assessment, and the brain region investigated. However, there is now sufficient evidence to suggest that caffeine use during pregnancy, especially prolonged, high levels of exposure, can alter fetal brain development and may contribute to adverse long-term neurodevelopmental outcomes.
| Original language | English |
|---|---|
| Title of host publication | General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions |
| Publisher | Academic Press |
| Chapter | 75 |
| Pages | 753-761 |
| Number of pages | 9 |
| Volume | 3 |
| ISBN (Electronic) | 9780128006771 |
| ISBN (Print) | 9780128006344 |
| DOIs | |
| Publication status | Published - 13 May 2016 |
Keywords
- Caffeine
- Development
- Fetus
- Neurodevelopment
- Pregnancy
Cite this
}
Caffeine and the Developing Brain : Molecular and Cellular Effects. / Atik, Anzari; Harding, Richard; De Matteo, Robert; Tolcos, Mary.
General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions. Vol. 3 Academic Press, 2016. p. 753-761.Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
TY - CHAP
T1 - Caffeine and the Developing Brain
T2 - Molecular and Cellular Effects
AU - Atik, Anzari
AU - Harding, Richard
AU - De Matteo, Robert
AU - Tolcos, Mary
PY - 2016/5/13
Y1 - 2016/5/13
N2 - Caffeine is a widely used, legal psychoactive drug, commonly ingested during pregnancy in tea, coffee, cola, and energy drinks. Caffeine concentrations in the fetus are similar to maternal levels as caffeine readily crosses the placenta. This chapter reviews data indicating that fetal caffeine exposure during pregnancy can potentially affect brain development, predominantly through its ability to antagonize adenosine receptors. Most of the available data are derived from animal experimentation and there are little data concerning the neurodevelopmental effects of caffeine in humans. The findings of experimental studies are often conflicting due to differences in species, the degree of caffeine exposure, developmental stage of the brain at exposure, age at assessment, and the brain region investigated. However, there is now sufficient evidence to suggest that caffeine use during pregnancy, especially prolonged, high levels of exposure, can alter fetal brain development and may contribute to adverse long-term neurodevelopmental outcomes.
AB - Caffeine is a widely used, legal psychoactive drug, commonly ingested during pregnancy in tea, coffee, cola, and energy drinks. Caffeine concentrations in the fetus are similar to maternal levels as caffeine readily crosses the placenta. This chapter reviews data indicating that fetal caffeine exposure during pregnancy can potentially affect brain development, predominantly through its ability to antagonize adenosine receptors. Most of the available data are derived from animal experimentation and there are little data concerning the neurodevelopmental effects of caffeine in humans. The findings of experimental studies are often conflicting due to differences in species, the degree of caffeine exposure, developmental stage of the brain at exposure, age at assessment, and the brain region investigated. However, there is now sufficient evidence to suggest that caffeine use during pregnancy, especially prolonged, high levels of exposure, can alter fetal brain development and may contribute to adverse long-term neurodevelopmental outcomes.
KW - Caffeine
KW - Development
KW - Fetus
KW - Neurodevelopment
KW - Pregnancy
UR - http://www.scopus.com/inward/record.url?scp=84978338366&partnerID=8YFLogxK
U2 - 10.1016/B978-0-12-800634-4.00075-5
DO - 10.1016/B978-0-12-800634-4.00075-5
M3 - Chapter (Book)
SN - 9780128006344
VL - 3
SP - 753
EP - 761
BT - General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions
PB - Academic Press
ER -