Caffeine and brain development in very preterm infants

Lex W. Doyle, Jeanie Cheong, Rod W. Hunt, Katherine J Lee, Deanne K Thompson, Peter G. Davis, Sandra Rees, Peter J. Anderson, Terrie Eleanor Inder

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective: Caffeine improves neurological outcome in very preterm infants, but the mechanisms responsible for this neurological benefit are unknown. The objective of this study was to assess whether caffeine influenced brain macro- or microstructural development in preterm infants. Methods: Seventy preterm infants <1,251 g birthweight randomly allocated to either caffeine (n = 33) or placebo (n = 37) underwent brain magnetic resonance imaging (MRI) at term-equivalent age; white and gray matter abnormalities were qualitatively scored, global and regional brain volumes were measured, and white matter microstructure was evaluated using diffusion-weighted imaging. Results: There were no significant differences between the groups in the extent of white matter or gray matter abnormality, or in global or regional brain volumes. In contrast, although only available in 28 children, caffeine exposure was associated with reductions in the apparent diffusion coefficient, and radial and axial diffusivity with the greatest impact in the superior brain regions. The alterations in diffusion measures were not mediated by lowering the rate of lung injury, known as bronchopulmonary dysplasia. Interpretation: These diffusion changes are consistent with improved white matter microstructural development in preterm infants who received caffeine. ANN NEUROL 2010;68:734-742

Original languageEnglish
Pages (from-to)734-742
Number of pages9
JournalAnnals of Neurology
Volume68
Issue number5
DOIs
Publication statusPublished - Nov 2010
Externally publishedYes

Cite this

Doyle, L. W., Cheong, J., Hunt, R. W., Lee, K. J., Thompson, D. K., Davis, P. G., ... Inder, T. E. (2010). Caffeine and brain development in very preterm infants. Annals of Neurology, 68(5), 734-742. https://doi.org/10.1002/ana.22098
Doyle, Lex W. ; Cheong, Jeanie ; Hunt, Rod W. ; Lee, Katherine J ; Thompson, Deanne K ; Davis, Peter G. ; Rees, Sandra ; Anderson, Peter J. ; Inder, Terrie Eleanor. / Caffeine and brain development in very preterm infants. In: Annals of Neurology. 2010 ; Vol. 68, No. 5. pp. 734-742.
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Doyle, LW, Cheong, J, Hunt, RW, Lee, KJ, Thompson, DK, Davis, PG, Rees, S, Anderson, PJ & Inder, TE 2010, 'Caffeine and brain development in very preterm infants' Annals of Neurology, vol. 68, no. 5, pp. 734-742. https://doi.org/10.1002/ana.22098

Caffeine and brain development in very preterm infants. / Doyle, Lex W.; Cheong, Jeanie; Hunt, Rod W.; Lee, Katherine J; Thompson, Deanne K; Davis, Peter G.; Rees, Sandra; Anderson, Peter J.; Inder, Terrie Eleanor.

In: Annals of Neurology, Vol. 68, No. 5, 11.2010, p. 734-742.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Rees, Sandra

AU - Anderson, Peter J.

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Doyle LW, Cheong J, Hunt RW, Lee KJ, Thompson DK, Davis PG et al. Caffeine and brain development in very preterm infants. Annals of Neurology. 2010 Nov;68(5):734-742. https://doi.org/10.1002/ana.22098