Cadaveric lobar lung transplantation: Technical aspects

Silvana F. Marasco, Stephanie Than, Dominic Keating, Glen Westall, Helen Whitford, Gregory Snell, Julian Gooi, Trevor Williams, Adrian Pick, Adam Zimmet, Geraldine A. Lee

Research output: Contribution to journalArticleResearchpeer-review

35 Citations (Scopus)

Abstract

Background: The use of lobar transplantation and other size reduction techniques has allowed larger donor lungs to be utilized for smaller recipients who tend to have longer waiting times for transplantation. However, despite these advantages, the techniques have not been widely adopted. We outline the surgical and sizing issues associated with this technique. Methods: A retrospective review of 23 consecutive patients who received lung transplantation with anatomic lobar reduction was performed, focusing on surgical technique and outcomes. Results: All 23 patients received an anatomic lobar reduction of between 1 and 3 lobes. Survival analysis showed no difference between the lobar reduction cohort and the other historically comparable lung transplant patients from our institution (p = 0.115). Percent predicted forced vital capacity and forced expiratory volume in 1 second at 3 months correlated with transplanted donor to recipient total lung capacity ratio, confirming the importance of correct sizing. Conclusions: Anatomic lobar reduction in lung transplantation is a safe and effective means of transplanting pediatric and small adult recipients, and urgently listed patients.

Original languageEnglish
Pages (from-to)1836-1842
Number of pages7
JournalThe Annals of Thoracic Surgery
Volume93
Issue number6
DOIs
Publication statusPublished - Jun 2012

Keywords

  • bilateral sequential lung transplant
  • BSL
  • cardiopulmonary bypass
  • chest X-ray
  • CPB
  • CXR
  • D/R
  • donor to recipient
  • ECMO
  • extracorporeal membrane oxygenation
  • FEV
  • forced expiratory volume in 1 second
  • forced vital capacity
  • FVC
  • left lower lobe of lung
  • LLL
  • maximal mid expiratory flow
  • MMEF
  • PGD
  • primary graft dysfunction
  • right lower lobe of lung
  • right middle lobe
  • right upper lobe
  • RLL
  • RML
  • RUL
  • single lung transplant
  • SL
  • TLC
  • total lung capacity

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