c-Rel: shaping CD4 regulatory T cell development in unexpected ways

Steven Demetrious Gerondakis; Thomas Fulford; Raelene Joy Grumont

doi:10.4161/trns.21309

c-Rel: shaping CD4 regulatory T cell development in unexpected ways

Steven Demetrious Gerondakis
, Thomas Fulford
, Raelene Joy Grumont

Australian Centre for Blood Diseases

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

In the thymus, sequential antigen and cytokine receptor signals direct the stepwise differentiation of multi-potential CD4+CD8+ thymic precursors into Foxp3+ CD4 regulatory T cells (Tregs). In this Point of View article we discuss our recent findings about how the c-Rel transcription factor orchestrates this developmental process.

Original language	English
Pages (from-to)	245 - 249
Number of pages	5
Journal	Transcription (Austin)
Volume	3
Issue number	5
DOIs	https://doi.org/10.4161/trns.21309
Publication status	Published - Sept 2012

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10.4161/trns.21309

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abstract = "In the thymus, sequential antigen and cytokine receptor signals direct the stepwise differentiation of multi-potential CD4+CD8+ thymic precursors into Foxp3+ CD4 regulatory T cells (Tregs). In this Point of View article we discuss our recent findings about how the c-Rel transcription factor orchestrates this developmental process.",

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AB - In the thymus, sequential antigen and cytokine receptor signals direct the stepwise differentiation of multi-potential CD4+CD8+ thymic precursors into Foxp3+ CD4 regulatory T cells (Tregs). In this Point of View article we discuss our recent findings about how the c-Rel transcription factor orchestrates this developmental process.

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c-Rel: shaping CD4 regulatory T cell development in unexpected ways

Abstract

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