Plasma cell migration is crucial to immunity, but little is known about the molecular regulators of their migratory programs. Here, we detail the critical role of the transcription factor c-Myb in determining plasma cell location. In the absence of c-Myb, no IgG(+) antigen-specific plasma cells were detected in the bone marrow after immunization or virus infection. This was correlated with a dramatic reduction of plasma cells in peripheral blood, mislocalization in spleen, and an inability of c-Myb-deficient plasma cells to migrate along a CXCL12 gradient. Therefore, c-Myb plays an essential, novel role in establishing the long-lived plasma cell population in the BM via responsiveness to chemokine migration cues.
Good-Jacobson, K. L., O'Donnell, K., Belz, G. T., Nutt, S. L., & Tarlinton, D. (2015). c-Myb is required for plasma cell migration to bone marrow after immunization or infection. Journal of Experimental Medicine, 212(7), 1001 - 1009. https://doi.org/10.1084/jem.20150191