c-Myb is required for plasma cell migration to bone marrow after immunization or infection

Kim L Good-Jacobson, Kristy O'Donnell, Gabrielle T Belz, Stephen L Nutt, David Tarlinton

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Plasma cell migration is crucial to immunity, but little is known about the molecular regulators of their migratory programs. Here, we detail the critical role of the transcription factor c-Myb in determining plasma cell location. In the absence of c-Myb, no IgG(+) antigen-specific plasma cells were detected in the bone marrow after immunization or virus infection. This was correlated with a dramatic reduction of plasma cells in peripheral blood, mislocalization in spleen, and an inability of c-Myb-deficient plasma cells to migrate along a CXCL12 gradient. Therefore, c-Myb plays an essential, novel role in establishing the long-lived plasma cell population in the BM via responsiveness to chemokine migration cues.
Original languageEnglish
Pages (from-to)1001 - 1009
Number of pages9
Journal Journal of Experimental Medicine
Volume212
Issue number7
DOIs
Publication statusPublished - 2015
Externally publishedYes

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