TY - JOUR
T1 - c-Myb is required for plasma cell migration to bone marrow after immunization or infection
AU - Good-Jacobson, Kim L
AU - O'Donnell, Kristy
AU - Belz, Gabrielle T
AU - Nutt, Stephen L
AU - Tarlinton, David
PY - 2015
Y1 - 2015
N2 - Plasma cell migration is crucial to immunity, but little is known about the molecular regulators of their migratory programs. Here, we detail the critical role of the transcription factor c-Myb in determining plasma cell location. In the absence of c-Myb, no IgG(+) antigen-specific plasma cells were detected in the bone marrow after immunization or virus infection. This was correlated with a dramatic reduction of plasma cells in peripheral blood, mislocalization in spleen, and an inability of c-Myb-deficient plasma cells to migrate along a CXCL12 gradient. Therefore, c-Myb plays an essential, novel role in establishing the long-lived plasma cell population in the BM via responsiveness to chemokine migration cues.
AB - Plasma cell migration is crucial to immunity, but little is known about the molecular regulators of their migratory programs. Here, we detail the critical role of the transcription factor c-Myb in determining plasma cell location. In the absence of c-Myb, no IgG(+) antigen-specific plasma cells were detected in the bone marrow after immunization or virus infection. This was correlated with a dramatic reduction of plasma cells in peripheral blood, mislocalization in spleen, and an inability of c-Myb-deficient plasma cells to migrate along a CXCL12 gradient. Therefore, c-Myb plays an essential, novel role in establishing the long-lived plasma cell population in the BM via responsiveness to chemokine migration cues.
UR - http://www.ncbi.nlm.nih.gov/pubmed/26077717
U2 - 10.1084/jem.20150191
DO - 10.1084/jem.20150191
M3 - Article
SN - 0022-1007
VL - 212
SP - 1001
EP - 1009
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 7
ER -