c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain

Jordane Malaterre, Theo Mantamadiotis, Sebastian Dworkin, Sally Lightowler, Qing Yang, Mark I Ransome, Ann Turnley, Nancy Rose Nichols, Nikla Emambokus, Jon Frampton, Robert G Ramsay

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.
Original languageEnglish
Pages (from-to)1 - 18
Number of pages18
JournalStem Cells
Volume1
Publication statusPublished - 2007

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