C-Jun expression in human neuropathies: A pilot study

Elspeth J. Hutton, Lucy Carty, Matilde Laurá, Henry Houlden, Michael P T Lunn, Sebastian Brandner, Rhona Mirsky, Kristjan Jessen, Reilly Mary

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35 Citations (Scopus)

Abstract

Schwann cell dedifferentiation following nerve injury is important to permit neural survival and axonal regrowth. Animal studies have shown that the transcription factor c-Jun is upregulated in Schwann cells of injured and pathological nerves where it acts as an important regulator of Schwann cell plasticity, promoting dedifferentiation and demyelination. This pilot immunohistochemical study investigates whether c-Jun is also upregulated in human neuropathies. We examined c-Jun expression in normal and diseased human nerves, as well as in dermal myelinated nerve fibres. Our findings show that although as predicted c-Jun is rarely expressed in normal nerves, it is expressed in Schwann cell nuclei of pathological nerves as predicted by animal studies. Pathological dermal myelinated nerve fibres also show clear nuclear c-Jun expression. Further studies of c-Jun expression will help clarify its role in human neuropathies. 

Original languageEnglish
Pages (from-to)295-303
Number of pages9
JournalJournal of the Peripheral Nervous System
Volume16
Issue number4
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

Keywords

  • axonal neuropathy
  • c-Jun
  • Schwann cell
  • skin biopsy

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