Burden and outcomes of severe pertussis infection in critically ill infants

Lahn Straney, Andreas Schibler, Anusha Ganeshalingham, Janet Alexander, Marino Festa, Anthony Slater, Graeme Maclaren, Luregn J. Schlapbach, Australian and New Zealand Intensive Care Society Centre for Outcomes and Resource Evaluation, Australian and New Zealand Intensive Care Society Paediatric Study Group

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Objectives: Despite World Health Organization endorsed immunization schedules, Bordetella pertussis continues to cause severe infections, predominantly in infants. There is a lack of data on the frequency and outcome of severe pertussis infections in infants requiring ICU admission. We aimed to describe admission rates, severity, mortality, and costs of pertussis infections in critically ill infants. Design: Binational observational multicenter study. Setting: Ten PICUs and 19 general ICUs in Australia and New Zealand contributing to the Australian and New Zealand Paediatric Intensive Care Registry. Patients: Infants below 1 year of age, requiring intensive care due to pertussis infection in Australia and New Zealand between 2002 and 2014. Measurements and Main Results: During the study period, 416 of 42,958 (1.0%) infants admitted to the ICU were diagnosed with pertussis. The estimated population-based ICU admission rate due to pertussis ranged from 2.1/100,000 infants to 18.6/100,000 infants. Admission rates were the highest among infants less than 60 days old (p < 0.0001). Two hundred six infants (49.5%) required mechanical ventilation, including 20 (4.8%) treated with high-frequency oscillatory ventilation, 16 (3.8%) with inhaled nitric oxide, and 7 (1.7%) with extracorporeal membrane oxygenation. Twenty of the 416 children (4.8%) died. The need for mechanical ventilation, high-frequency oscillatory ventilation, nitric oxide, and extracorporeal membrane oxygenation were significantly associated with mortality (p < 0.01). Direct severe pertussis-related hospitalization costs were in excess of USD$1,000,000 per year. Conclusions: Pertussis continues to cause significant morbidity and mortality in infants, in particular during the first months of life. Improved strategies are required to reduce the significant healthcare costs and disease burden of this vaccine-preventable disease.

Original languageEnglish
Pages (from-to)735-742
Number of pages8
JournalPediatric Critical Care Medicine
Volume17
Issue number8
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • infant
  • intensive care
  • mortality
  • pertussis
  • vaccination
  • ventilation

Cite this

Straney, L., Schibler, A., Ganeshalingham, A., Alexander, J., Festa, M., Slater, A., ... Australian and New Zealand Intensive Care Society Paediatric Study Group (2016). Burden and outcomes of severe pertussis infection in critically ill infants. Pediatric Critical Care Medicine, 17(8), 735-742. https://doi.org/10.1097/PCC.0000000000000851
Straney, Lahn ; Schibler, Andreas ; Ganeshalingham, Anusha ; Alexander, Janet ; Festa, Marino ; Slater, Anthony ; Maclaren, Graeme ; Schlapbach, Luregn J. ; Australian and New Zealand Intensive Care Society Centre for Outcomes and Resource Evaluation ; Australian and New Zealand Intensive Care Society Paediatric Study Group. / Burden and outcomes of severe pertussis infection in critically ill infants. In: Pediatric Critical Care Medicine. 2016 ; Vol. 17, No. 8. pp. 735-742.
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abstract = "Objectives: Despite World Health Organization endorsed immunization schedules, Bordetella pertussis continues to cause severe infections, predominantly in infants. There is a lack of data on the frequency and outcome of severe pertussis infections in infants requiring ICU admission. We aimed to describe admission rates, severity, mortality, and costs of pertussis infections in critically ill infants. Design: Binational observational multicenter study. Setting: Ten PICUs and 19 general ICUs in Australia and New Zealand contributing to the Australian and New Zealand Paediatric Intensive Care Registry. Patients: Infants below 1 year of age, requiring intensive care due to pertussis infection in Australia and New Zealand between 2002 and 2014. Measurements and Main Results: During the study period, 416 of 42,958 (1.0{\%}) infants admitted to the ICU were diagnosed with pertussis. The estimated population-based ICU admission rate due to pertussis ranged from 2.1/100,000 infants to 18.6/100,000 infants. Admission rates were the highest among infants less than 60 days old (p < 0.0001). Two hundred six infants (49.5{\%}) required mechanical ventilation, including 20 (4.8{\%}) treated with high-frequency oscillatory ventilation, 16 (3.8{\%}) with inhaled nitric oxide, and 7 (1.7{\%}) with extracorporeal membrane oxygenation. Twenty of the 416 children (4.8{\%}) died. The need for mechanical ventilation, high-frequency oscillatory ventilation, nitric oxide, and extracorporeal membrane oxygenation were significantly associated with mortality (p < 0.01). Direct severe pertussis-related hospitalization costs were in excess of USD$1,000,000 per year. Conclusions: Pertussis continues to cause significant morbidity and mortality in infants, in particular during the first months of life. Improved strategies are required to reduce the significant healthcare costs and disease burden of this vaccine-preventable disease.",
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Straney, L, Schibler, A, Ganeshalingham, A, Alexander, J, Festa, M, Slater, A, Maclaren, G, Schlapbach, LJ, Australian and New Zealand Intensive Care Society Centre for Outcomes and Resource Evaluation & Australian and New Zealand Intensive Care Society Paediatric Study Group 2016, 'Burden and outcomes of severe pertussis infection in critically ill infants', Pediatric Critical Care Medicine, vol. 17, no. 8, pp. 735-742. https://doi.org/10.1097/PCC.0000000000000851

Burden and outcomes of severe pertussis infection in critically ill infants. / Straney, Lahn; Schibler, Andreas; Ganeshalingham, Anusha; Alexander, Janet; Festa, Marino; Slater, Anthony; Maclaren, Graeme; Schlapbach, Luregn J.; Australian and New Zealand Intensive Care Society Centre for Outcomes and Resource Evaluation; Australian and New Zealand Intensive Care Society Paediatric Study Group.

In: Pediatric Critical Care Medicine, Vol. 17, No. 8, 01.08.2016, p. 735-742.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Ganeshalingham, Anusha

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