Brown adipose tissue thermogenesis heats brain and body as part of the brain-coordinated ultradian basic rest-activity cycle

Y Ootsuka, R C de Menezes, D V Zaretsky, A Alimoradian, J Hunt, Aneta Stefanidis, Brian John Oldfield, W W Blessing

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Brown adipose tissue (BAT), body and brain temperatures, as well as behavioral activity, arterial pressure and heart rate, increase episodically during the waking (dark) phase of the circadian cycle in rats. Phase-linking of combinations of these ultradian (/=0.5 degrees C) occurred in an irregular episodic manner every 94+/-43 min (mean+/-SD). Varying the temperature over a wider range (18-30 degrees C) on different days did not change the periodicity, and neither body nor brain temperature fell before BAT temperature episodic increases.......
Original languageEnglish
Pages (from-to)849 - 861
Number of pages13
Issue number2
Publication statusPublished - 2009

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