TY - JOUR
T1 - Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors
AU - Semple, Bridgette D.
AU - Noble-Haeusslein, Linda J.
PY - 2011/6
Y1 - 2011/6
N2 - In a recent issue of Experimental Neurology, Sauerbeck and colleagues demonstrated that treatment with the peroxisome proliferator-activated receptor (PPAR) agonist Pioglitazone after experimental traumatic brain injury (TBI) in rats was protective against mitochondrial dysfunction, cognitive impairment, cortical tissue loss and microglial activation. In this commentary, we review the key findings of this work and their relevance to previous and future neurotrauma research. More broadly, we speculate about their significance in the context of developing therapeutic strategies for a wide range of neuroinflammatory conditions.
AB - In a recent issue of Experimental Neurology, Sauerbeck and colleagues demonstrated that treatment with the peroxisome proliferator-activated receptor (PPAR) agonist Pioglitazone after experimental traumatic brain injury (TBI) in rats was protective against mitochondrial dysfunction, cognitive impairment, cortical tissue loss and microglial activation. In this commentary, we review the key findings of this work and their relevance to previous and future neurotrauma research. More broadly, we speculate about their significance in the context of developing therapeutic strategies for a wide range of neuroinflammatory conditions.
KW - Neuroprotection
KW - Peroxisome proliferator-activated receptors
KW - Pioglitazone
KW - Traumatic brain injury
UR - http://www.scopus.com/inward/record.url?scp=79956091561&partnerID=8YFLogxK
U2 - 10.1016/j.expneurol.2011.02.002
DO - 10.1016/j.expneurol.2011.02.002
M3 - Comment / Debate
C2 - 21316363
AN - SCOPUS:79956091561
SN - 0014-4886
VL - 229
SP - 195
EP - 197
JO - Experimental Neurology
JF - Experimental Neurology
IS - 2
ER -