Broad-spectrum neuroprotection against traumatic brain injury by agonism of peroxisome proliferator-activated receptors

Bridgette D. Semple, Linda J. Noble-Haeusslein

Research output: Contribution to journalComment / DebateOtherpeer-review

9 Citations (Scopus)


In a recent issue of Experimental Neurology, Sauerbeck and colleagues demonstrated that treatment with the peroxisome proliferator-activated receptor (PPAR) agonist Pioglitazone after experimental traumatic brain injury (TBI) in rats was protective against mitochondrial dysfunction, cognitive impairment, cortical tissue loss and microglial activation. In this commentary, we review the key findings of this work and their relevance to previous and future neurotrauma research. More broadly, we speculate about their significance in the context of developing therapeutic strategies for a wide range of neuroinflammatory conditions.

Original languageEnglish
Pages (from-to)195-197
Number of pages3
JournalExperimental Neurology
Issue number2
Publication statusPublished - Jun 2011
Externally publishedYes


  • Neuroprotection
  • Peroxisome proliferator-activated receptors
  • Pioglitazone
  • Traumatic brain injury

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