Bringing evidence from press release to the clinic in the era of COVID-19

Research output: Contribution to journalReview ArticleOtherpeer-review

Abstract

The urgent need to develop effective therapeutics and disseminate information from clinical studies has led to data from clinical trials being made available by alternate methods prior to peer-reviewed publication, including press releases, social media and pre-print papers. While this allows clinicians more open access to these data, a trust has to be placed with the investigators releasing these data without the availability of scientifically rigorous peer review. The examples of results from trials studying dexamethasone and hydroxychloroquine for treatment of COVID-19 have had contrasting outcomes, including the potential for significant numbers of lives saved with the early release of results from the RECOVERY trial studying dexamethasone contrasting with unsubstantiated data being presented from trials studying hydroxychloroquine. Clinicians and researchers must maintain a healthy scepticism when reviewing results prior to peer-reviewed publication, but also consider when these opportunities may allow for early implementation of potentially lifesaving interventions for people infected with COVID-19.

Original languageEnglish
Pages (from-to)547-549
Number of pages3
JournalJournal of Antimicrobial Chemotherapy
Volume76
Issue number3
DOIs
Publication statusPublished - 11 Feb 2021

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