Bridging the Gap between Connectome and Transcriptome

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

The recent construction of brain-wide gene expression atlases, which measure the transcriptional activity of thousands of genes in multiple anatomical locations, has made it possible to connect spatial variations in gene expression to distributed properties of connectome structure and function. These analyses have revealed that spatial patterning of gene expression and neuronal connectivity are closely linked, following broad spatial gradients that track regional variations in microcircuitry, inter-regional connectivity, and functional specialisation. Superimposed on these gradients are more specific associations between gene expression and connectome topology that appear conserved across diverse species and different resolution scales. These findings demonstrate the utility of brain-wide gene expression atlases for bridging the gap between molecular function and large-scale connectome organisation in health and disease.

Original languageEnglish
Pages (from-to)34-50
Number of pages17
JournalTrends in Cognitive Sciences
Volume23
Issue number1
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • complex network
  • DNA
  • graph analysis
  • hub
  • magnetic resonance imaging
  • microarray

Cite this

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title = "Bridging the Gap between Connectome and Transcriptome",
abstract = "The recent construction of brain-wide gene expression atlases, which measure the transcriptional activity of thousands of genes in multiple anatomical locations, has made it possible to connect spatial variations in gene expression to distributed properties of connectome structure and function. These analyses have revealed that spatial patterning of gene expression and neuronal connectivity are closely linked, following broad spatial gradients that track regional variations in microcircuitry, inter-regional connectivity, and functional specialisation. Superimposed on these gradients are more specific associations between gene expression and connectome topology that appear conserved across diverse species and different resolution scales. These findings demonstrate the utility of brain-wide gene expression atlases for bridging the gap between molecular function and large-scale connectome organisation in health and disease.",
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Bridging the Gap between Connectome and Transcriptome. / Fornito, Alex; Arnatkevičiūtė, Aurina; Fulcher, Ben D.

In: Trends in Cognitive Sciences, Vol. 23, No. 1, 01.01.2019, p. 34-50.

Research output: Contribution to journalReview ArticleResearchpeer-review

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