Bridged bicyclic peptides: Structure and function

Varsha J. Thombare; Craig A. Hutton

doi:10.1002/pep2.24057

Bridged bicyclic peptides: Structure and function

Varsha J. Thombare
, Craig A. Hutton

Research output: Contribution to journal › Review Article › Other › peer-review

20 Citations (Scopus)

Abstract

Bicyclic peptides are conformationally rigid molecules that can bind with high affinity and specificity to their protein target, yet are significantly more protease stable than their linear or monocyclic counterparts. This emerging class of peptides has great potential for the development of novel peptide therapeutics and molecular probes. In this review, we highlight the structural complexity, synthesis/biosynthesis, and biological applications of bridged bicyclic peptides.

Original language	English
Article number	e24057
Number of pages	14
Journal	Peptide Science
Volume	110
Issue number	3
DOIs	https://doi.org/10.1002/pep2.24057
Publication status	Published - May 2018
Externally published	Yes

Keywords

bicyclic peptides
crosslinked peptides
cyclic peptides

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10.1002/pep2.24057

Cite this

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title = "Bridged bicyclic peptides: Structure and function",

abstract = "Bicyclic peptides are conformationally rigid molecules that can bind with high affinity and specificity to their protein target, yet are significantly more protease stable than their linear or monocyclic counterparts. This emerging class of peptides has great potential for the development of novel peptide therapeutics and molecular probes. In this review, we highlight the structural complexity, synthesis/biosynthesis, and biological applications of bridged bicyclic peptides.",

keywords = "bicyclic peptides, crosslinked peptides, cyclic peptides",

author = "Thombare, \{Varsha J.\} and Hutton, \{Craig A.\}",

note = "Funding Information: Australian Research Council, Grant Numbers: DP120101454, DP140100174, DP150100692 Publisher Copyright: {\textcopyright} 2018 Wiley Periodicals, Inc.",

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T2 - Structure and function

AU - Thombare, Varsha J.

AU - Hutton, Craig A.

PY - 2018/5

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AB - Bicyclic peptides are conformationally rigid molecules that can bind with high affinity and specificity to their protein target, yet are significantly more protease stable than their linear or monocyclic counterparts. This emerging class of peptides has great potential for the development of novel peptide therapeutics and molecular probes. In this review, we highlight the structural complexity, synthesis/biosynthesis, and biological applications of bridged bicyclic peptides.

KW - bicyclic peptides

KW - crosslinked peptides

KW - cyclic peptides

UR - https://www.scopus.com/pages/publications/85051771009

U2 - 10.1002/pep2.24057

DO - 10.1002/pep2.24057

M3 - Review Article

AN - SCOPUS:85051771009

SN - 2475-8817

VL - 110

JO - Peptide Science

JF - Peptide Science

IS - 3

M1 - e24057

ER -

Bridged bicyclic peptides: Structure and function

Abstract

Keywords

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