Bridged bicyclic peptides: Structure and function

Varsha J. Thombare, Craig A. Hutton

Research output: Contribution to journalReview ArticleOtherpeer-review

10 Citations (Scopus)


Bicyclic peptides are conformationally rigid molecules that can bind with high affinity and specificity to their protein target, yet are significantly more protease stable than their linear or monocyclic counterparts. This emerging class of peptides has great potential for the development of novel peptide therapeutics and molecular probes. In this review, we highlight the structural complexity, synthesis/biosynthesis, and biological applications of bridged bicyclic peptides.

Original languageEnglish
Article numbere24057
Number of pages14
JournalPeptide Science
Issue number3
Publication statusPublished - May 2018
Externally publishedYes


  • bicyclic peptides
  • crosslinked peptides
  • cyclic peptides

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