Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors

Kathryn R Greenop, Helen D Bailey, Margaret Miller, Rodney J Scott, John Attia, Lesley J Ashton, Peter Downie, Bruce K Armstrong, Elizabeth Milne

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is known of their etiology. In 2 nationwide case-control studies we investigated whether breastfeeding, age of food introduction, or early diet are associated with the risk of these cancers. Cases aged 0-14 years were identified from Australian pediatric oncology units between 2003 and 2007 (ALL) and 2005 and 2010 (CBT) and population-based controls through nationwide random-digit dialing. Mothers completed questionnaires giving details of infant feeding up to the age of 2 yr. Data from 322 ALL cases, 679 ALL controls, 299 CBT cases, and 733 CBT controls were analysed using unconditional logistic regression. Breastfeeding was associated with a reduced risk of ALL [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.32, 0.84), regardless of duration. Introduction of artificial formula within 14 days of birth was positively associated with ALL (OR = 1.57, 95% CI: 1.03, 2.37), as was exclusive formula feeding to 6 mo (OR = 1.81, 95% CI: 1.07, 3.05). No associations were seen between breastfeeding or formula use and risk of CBT. Our results suggest that breastfeeding and delayed introduction of artificial formula may reduce the risk of ALL but not CBT.

Original languageEnglish
Pages (from-to)431-441
Number of pages11
JournalNutrition and Cancer-An International Journal
Volume67
Issue number3
DOIs
Publication statusPublished - 3 Apr 2015
Externally publishedYes

Cite this

Greenop, Kathryn R ; Bailey, Helen D ; Miller, Margaret ; Scott, Rodney J ; Attia, John ; Ashton, Lesley J ; Downie, Peter ; Armstrong, Bruce K ; Milne, Elizabeth. / Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors. In: Nutrition and Cancer-An International Journal. 2015 ; Vol. 67, No. 3. pp. 431-441.
@article{35fa2496422e4d189d5a6c1763e27510,
title = "Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors",
abstract = "Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is known of their etiology. In 2 nationwide case-control studies we investigated whether breastfeeding, age of food introduction, or early diet are associated with the risk of these cancers. Cases aged 0-14 years were identified from Australian pediatric oncology units between 2003 and 2007 (ALL) and 2005 and 2010 (CBT) and population-based controls through nationwide random-digit dialing. Mothers completed questionnaires giving details of infant feeding up to the age of 2 yr. Data from 322 ALL cases, 679 ALL controls, 299 CBT cases, and 733 CBT controls were analysed using unconditional logistic regression. Breastfeeding was associated with a reduced risk of ALL [odds ratio (OR) = 0.52, 95{\%} confidence interval (CI): 0.32, 0.84), regardless of duration. Introduction of artificial formula within 14 days of birth was positively associated with ALL (OR = 1.57, 95{\%} CI: 1.03, 2.37), as was exclusive formula feeding to 6 mo (OR = 1.81, 95{\%} CI: 1.07, 3.05). No associations were seen between breastfeeding or formula use and risk of CBT. Our results suggest that breastfeeding and delayed introduction of artificial formula may reduce the risk of ALL but not CBT.",
author = "Greenop, {Kathryn R} and Bailey, {Helen D} and Margaret Miller and Scott, {Rodney J} and John Attia and Ashton, {Lesley J} and Peter Downie and Armstrong, {Bruce K} and Elizabeth Milne",
year = "2015",
month = "4",
day = "3",
doi = "10.1080/01635581.2015.998839",
language = "English",
volume = "67",
pages = "431--441",
journal = "Nutrition and Cancer-An International Journal",
issn = "0163-5581",
publisher = "Taylor & Francis",
number = "3",

}

Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors. / Greenop, Kathryn R; Bailey, Helen D; Miller, Margaret; Scott, Rodney J; Attia, John; Ashton, Lesley J; Downie, Peter; Armstrong, Bruce K; Milne, Elizabeth.

In: Nutrition and Cancer-An International Journal, Vol. 67, No. 3, 03.04.2015, p. 431-441.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Breastfeeding and nutrition to 2 years of age and risk of childhood acute lymphoblastic leukemia and brain tumors

AU - Greenop, Kathryn R

AU - Bailey, Helen D

AU - Miller, Margaret

AU - Scott, Rodney J

AU - Attia, John

AU - Ashton, Lesley J

AU - Downie, Peter

AU - Armstrong, Bruce K

AU - Milne, Elizabeth

PY - 2015/4/3

Y1 - 2015/4/3

N2 - Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is known of their etiology. In 2 nationwide case-control studies we investigated whether breastfeeding, age of food introduction, or early diet are associated with the risk of these cancers. Cases aged 0-14 years were identified from Australian pediatric oncology units between 2003 and 2007 (ALL) and 2005 and 2010 (CBT) and population-based controls through nationwide random-digit dialing. Mothers completed questionnaires giving details of infant feeding up to the age of 2 yr. Data from 322 ALL cases, 679 ALL controls, 299 CBT cases, and 733 CBT controls were analysed using unconditional logistic regression. Breastfeeding was associated with a reduced risk of ALL [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.32, 0.84), regardless of duration. Introduction of artificial formula within 14 days of birth was positively associated with ALL (OR = 1.57, 95% CI: 1.03, 2.37), as was exclusive formula feeding to 6 mo (OR = 1.81, 95% CI: 1.07, 3.05). No associations were seen between breastfeeding or formula use and risk of CBT. Our results suggest that breastfeeding and delayed introduction of artificial formula may reduce the risk of ALL but not CBT.

AB - Acute lymphoblastic leukemia (ALL) and childhood brain tumors (CBT) are 2 of the most common forms of childhood cancer, but little is known of their etiology. In 2 nationwide case-control studies we investigated whether breastfeeding, age of food introduction, or early diet are associated with the risk of these cancers. Cases aged 0-14 years were identified from Australian pediatric oncology units between 2003 and 2007 (ALL) and 2005 and 2010 (CBT) and population-based controls through nationwide random-digit dialing. Mothers completed questionnaires giving details of infant feeding up to the age of 2 yr. Data from 322 ALL cases, 679 ALL controls, 299 CBT cases, and 733 CBT controls were analysed using unconditional logistic regression. Breastfeeding was associated with a reduced risk of ALL [odds ratio (OR) = 0.52, 95% confidence interval (CI): 0.32, 0.84), regardless of duration. Introduction of artificial formula within 14 days of birth was positively associated with ALL (OR = 1.57, 95% CI: 1.03, 2.37), as was exclusive formula feeding to 6 mo (OR = 1.81, 95% CI: 1.07, 3.05). No associations were seen between breastfeeding or formula use and risk of CBT. Our results suggest that breastfeeding and delayed introduction of artificial formula may reduce the risk of ALL but not CBT.

UR - http://www.scopus.com/inward/record.url?scp=84926519897&partnerID=8YFLogxK

U2 - 10.1080/01635581.2015.998839

DO - 10.1080/01635581.2015.998839

M3 - Article

VL - 67

SP - 431

EP - 441

JO - Nutrition and Cancer-An International Journal

JF - Nutrition and Cancer-An International Journal

SN - 0163-5581

IS - 3

ER -