Breakthrough Scedosporium prolificans infection while receiving voriconazole prophylaxis in an allogeneic stem cell transplant recipient

Steven Y Tong, Anton Yariv Peleg, J Yoong, R Handke, Jeffrey Szer, Monica Slavin

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43 Citations (Scopus)

Abstract

Breakthrough invasive fungal infections among patients with hematologic malignancies receiving voriconazole are being reported with increasing frequency, with zygomycete infections predominating. We report a case of disseminated Scedosporium prolificans infection in a patient receiving voriconazole prophylaxis. Despite poor in vitro activity of voriconazole for this organism, synergy studies using the checkerboard method demonstrated synergy with the combination of voriconazole and terbinafine. This regimen, in conjunction with central venous line removal and intravitreal voriconazole, contributed to the recovery of the patient. S. prolificans is a life-threatening mold that should be considered in patients with breakthrough invasive fungal infections while on voriconazole prophylaxis.
Original languageEnglish
Pages (from-to)241 - 243
Number of pages3
JournalTransplant Infectious Disease
Volume9
Issue number3
DOIs
Publication statusPublished - 2007

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