Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 976 - 983 |
| Number of pages | 8 |
| Journal | Diabetes Care |
| Volume | 35 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2012 |
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Breaking up prolonged sitting reduces postprandial glucose and insulin responses. / Dunstan, David W; Kingwell, Bronwyn A; Larsen, Robyn; Healy, Genevive N; Cerin, Ester; Hamilton, Marc T; Shaw, Jonathan Edward; Bertovic, David A; Zimmet, Paul Zev; Salmon, Jo; Owen, Neville.
In: Diabetes Care, Vol. 35, No. 5, 2012, p. 976 - 983.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Breaking up prolonged sitting reduces postprandial glucose and insulin responses
AU - Dunstan, David W
AU - Kingwell, Bronwyn A
AU - Larsen, Robyn
AU - Healy, Genevive N
AU - Cerin, Ester
AU - Hamilton, Marc T
AU - Shaw, Jonathan Edward
AU - Bertovic, David A
AU - Zimmet, Paul Zev
AU - Salmon, Jo
AU - Owen, Neville
PY - 2012
Y1 - 2012
N2 - OBJECTIVE - Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking. RESEARCH DESIGN AND METHODS - Overweight/obese adults (n = 19), aged 45-65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95 CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments. RESULTS - The glucose iAUC (mmol/L) ? h after both activity-break conditions was reduced (light: 5.2 [4.1-6.6]; moderate: 4.9 [3.8-6.1]; both P <0.01) compared with uninterrupted sitting (6.9 [5.5-8.7]). Insulin iAUC (pmol/L) ? h was also reduced with both activity-break conditions (light: 633.6 [552.4-727.1];moderate: 637.6 [555.5-731.9], P <0.0001) compared with uninterrupted sitting (828.6 [722.0-950.9]). CONCLUSIONS - Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.
AB - OBJECTIVE - Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking. RESEARCH DESIGN AND METHODS - Overweight/obese adults (n = 19), aged 45-65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95 CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments. RESULTS - The glucose iAUC (mmol/L) ? h after both activity-break conditions was reduced (light: 5.2 [4.1-6.6]; moderate: 4.9 [3.8-6.1]; both P <0.01) compared with uninterrupted sitting (6.9 [5.5-8.7]). Insulin iAUC (pmol/L) ? h was also reduced with both activity-break conditions (light: 633.6 [552.4-727.1];moderate: 637.6 [555.5-731.9], P <0.0001) compared with uninterrupted sitting (828.6 [722.0-950.9]). CONCLUSIONS - Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.
U2 - 10.2337/dc11-1931
DO - 10.2337/dc11-1931
M3 - Article
VL - 35
SP - 976
EP - 983
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 5
ER -