Breaking up prolonged sitting reduces postprandial glucose and insulin responses

David W Dunstan, Bronwyn A Kingwell, Robyn Larsen, Genevive N Healy, Ester Cerin, Marc T Hamilton, Jonathan Edward Shaw, David A Bertovic, Paul Zev Zimmet, Jo Salmon, Neville Owen

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

OBJECTIVE - Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking. RESEARCH DESIGN AND METHODS - Overweight/obese adults (n = 19), aged 45-65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95 CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments. RESULTS - The glucose iAUC (mmol/L) ? h after both activity-break conditions was reduced (light: 5.2 [4.1-6.6]; moderate: 4.9 [3.8-6.1]; both P <0.01) compared with uninterrupted sitting (6.9 [5.5-8.7]). Insulin iAUC (pmol/L) ? h was also reduced with both activity-break conditions (light: 633.6 [552.4-727.1];moderate: 637.6 [555.5-731.9], P <0.0001) compared with uninterrupted sitting (828.6 [722.0-950.9]). CONCLUSIONS - Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.
Original languageEnglish
Pages (from-to)976 - 983
Number of pages8
JournalDiabetes Care
Volume35
Issue number5
DOIs
Publication statusPublished - 2012

Cite this

Dunstan, David W ; Kingwell, Bronwyn A ; Larsen, Robyn ; Healy, Genevive N ; Cerin, Ester ; Hamilton, Marc T ; Shaw, Jonathan Edward ; Bertovic, David A ; Zimmet, Paul Zev ; Salmon, Jo ; Owen, Neville. / Breaking up prolonged sitting reduces postprandial glucose and insulin responses. In: Diabetes Care. 2012 ; Vol. 35, No. 5. pp. 976 - 983.
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title = "Breaking up prolonged sitting reduces postprandial glucose and insulin responses",
abstract = "OBJECTIVE - Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking. RESEARCH DESIGN AND METHODS - Overweight/obese adults (n = 19), aged 45-65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95 CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments. RESULTS - The glucose iAUC (mmol/L) ? h after both activity-break conditions was reduced (light: 5.2 [4.1-6.6]; moderate: 4.9 [3.8-6.1]; both P <0.01) compared with uninterrupted sitting (6.9 [5.5-8.7]). Insulin iAUC (pmol/L) ? h was also reduced with both activity-break conditions (light: 633.6 [552.4-727.1];moderate: 637.6 [555.5-731.9], P <0.0001) compared with uninterrupted sitting (828.6 [722.0-950.9]). CONCLUSIONS - Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.",
author = "Dunstan, {David W} and Kingwell, {Bronwyn A} and Robyn Larsen and Healy, {Genevive N} and Ester Cerin and Hamilton, {Marc T} and Shaw, {Jonathan Edward} and Bertovic, {David A} and Zimmet, {Paul Zev} and Jo Salmon and Neville Owen",
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Breaking up prolonged sitting reduces postprandial glucose and insulin responses. / Dunstan, David W; Kingwell, Bronwyn A; Larsen, Robyn; Healy, Genevive N; Cerin, Ester; Hamilton, Marc T; Shaw, Jonathan Edward; Bertovic, David A; Zimmet, Paul Zev; Salmon, Jo; Owen, Neville.

In: Diabetes Care, Vol. 35, No. 5, 2012, p. 976 - 983.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Breaking up prolonged sitting reduces postprandial glucose and insulin responses

AU - Dunstan, David W

AU - Kingwell, Bronwyn A

AU - Larsen, Robyn

AU - Healy, Genevive N

AU - Cerin, Ester

AU - Hamilton, Marc T

AU - Shaw, Jonathan Edward

AU - Bertovic, David A

AU - Zimmet, Paul Zev

AU - Salmon, Jo

AU - Owen, Neville

PY - 2012

Y1 - 2012

N2 - OBJECTIVE - Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking. RESEARCH DESIGN AND METHODS - Overweight/obese adults (n = 19), aged 45-65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95 CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments. RESULTS - The glucose iAUC (mmol/L) ? h after both activity-break conditions was reduced (light: 5.2 [4.1-6.6]; moderate: 4.9 [3.8-6.1]; both P <0.01) compared with uninterrupted sitting (6.9 [5.5-8.7]). Insulin iAUC (pmol/L) ? h was also reduced with both activity-break conditions (light: 633.6 [552.4-727.1];moderate: 637.6 [555.5-731.9], P <0.0001) compared with uninterrupted sitting (828.6 [722.0-950.9]). CONCLUSIONS - Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.

AB - OBJECTIVE - Observational studies show breaking up prolonged sitting has beneficial associations with cardiometabolic risk markers, but intervention studies are required to investigate causality. We examined the acute effects on postprandial glucose and insulin levels of uninterrupted sitting compared with sitting interrupted by brief bouts of light- or moderate-intensity walking. RESEARCH DESIGN AND METHODS - Overweight/obese adults (n = 19), aged 45-65 years, were recruited for a randomized three-period, three-treatment acute crossover trial: 1) uninterrupted sitting; 2) seated with 2-min bouts of light-intensity walking every 20 min; and 3) seated with 2-min bouts of moderate-intensity walking every 20 min. A standardized test drink was provided after an initial 2-h period of uninterrupted sitting. The positive incremental area under curves (iAUC) for glucose and insulin (mean [95 CI]) for the 5 h after the test drink (75 g glucose, 50 g fat) were calculated for the respective treatments. RESULTS - The glucose iAUC (mmol/L) ? h after both activity-break conditions was reduced (light: 5.2 [4.1-6.6]; moderate: 4.9 [3.8-6.1]; both P <0.01) compared with uninterrupted sitting (6.9 [5.5-8.7]). Insulin iAUC (pmol/L) ? h was also reduced with both activity-break conditions (light: 633.6 [552.4-727.1];moderate: 637.6 [555.5-731.9], P <0.0001) compared with uninterrupted sitting (828.6 [722.0-950.9]). CONCLUSIONS - Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults. This may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.

U2 - 10.2337/dc11-1931

DO - 10.2337/dc11-1931

M3 - Article

VL - 35

SP - 976

EP - 983

JO - Diabetes Care

JF - Diabetes Care

SN - 0149-5992

IS - 5

ER -