Brain substrates of unhealthy versus healthy food choices

Influence of homeostatic status and body mass index

IH Harding, ZB Andrews, F Mata, S. Orlandea, I. Martínez-Zalacaín, C. Soriano-Mas, E. Stice, A. Verdejo-Garcia

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Background/Objectives:Unhealthy dietary choices are a major contributor to harmful weight gain and obesity. This study interrogated the brain substrates of unhealthy versus healthy food choices in vivo, and evaluated the influence of hunger state and body mass index (BMI) on brain activation and connectivity.Subjects/Methods:Thirty adults (BMI: 18-38 kg m '2) performed a food-choice task involving preference-based selection between beverage pairs consisting of high-calorie (unhealthy) or low-calorie (healthy) options, concurrent with functional magnetic resonance imaging (fMRI). Selected food stimuli were delivered to participants using an MRI-compatible gustometer. fMRI scans were performed both after 10-h fasting and when sated. Brain activation and hypothalamic functional connectivity were assessed when selecting between unhealthy-healthy beverage pairings, relative to unhealthy-unhealthy and healthy-healthy options. Results were considered significant at cluster-based family-wise error corrected P<0.05.Results:Selecting between unhealthy and healthy foods elicited significant activation in the hypothalamus, the medial and dorsolateral prefrontal cortices, the anterior insula and the posterior cingulate. Hunger was associated with higher activation within the ventromedial and dorsolateral prefrontal cortices, as well as lower connectivity between the hypothalamus and both the ventromedial prefrontal cortex and dorsal striatum. Critically, people with higher BMI showed lower activation of the hypothalamus - regardless of hunger state - and higher activation of the ventromedial prefrontal cortex when hungry.Conclusions:People who are overweight and obese have weaker activation of brain regions involved in energy regulation and greater activation of reward valuation regions while making choices between unhealthy and healthy foods. These results provide evidence for a shift towards hedonic-based, and away from energy-based, food selection in obesity.

Original languageEnglish
Pages (from-to)448-454
Number of pages7
JournalInternational Journal of Obesity
Volume42
Issue number3
DOIs
Publication statusPublished - 1 Mar 2018

Keywords

  • cognitive neuroscience
  • feeding behaviour

Cite this

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title = "Brain substrates of unhealthy versus healthy food choices: Influence of homeostatic status and body mass index",
abstract = "Background/Objectives:Unhealthy dietary choices are a major contributor to harmful weight gain and obesity. This study interrogated the brain substrates of unhealthy versus healthy food choices in vivo, and evaluated the influence of hunger state and body mass index (BMI) on brain activation and connectivity.Subjects/Methods:Thirty adults (BMI: 18-38 kg m '2) performed a food-choice task involving preference-based selection between beverage pairs consisting of high-calorie (unhealthy) or low-calorie (healthy) options, concurrent with functional magnetic resonance imaging (fMRI). Selected food stimuli were delivered to participants using an MRI-compatible gustometer. fMRI scans were performed both after 10-h fasting and when sated. Brain activation and hypothalamic functional connectivity were assessed when selecting between unhealthy-healthy beverage pairings, relative to unhealthy-unhealthy and healthy-healthy options. Results were considered significant at cluster-based family-wise error corrected P<0.05.Results:Selecting between unhealthy and healthy foods elicited significant activation in the hypothalamus, the medial and dorsolateral prefrontal cortices, the anterior insula and the posterior cingulate. Hunger was associated with higher activation within the ventromedial and dorsolateral prefrontal cortices, as well as lower connectivity between the hypothalamus and both the ventromedial prefrontal cortex and dorsal striatum. Critically, people with higher BMI showed lower activation of the hypothalamus - regardless of hunger state - and higher activation of the ventromedial prefrontal cortex when hungry.Conclusions:People who are overweight and obese have weaker activation of brain regions involved in energy regulation and greater activation of reward valuation regions while making choices between unhealthy and healthy foods. These results provide evidence for a shift towards hedonic-based, and away from energy-based, food selection in obesity.",
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Brain substrates of unhealthy versus healthy food choices : Influence of homeostatic status and body mass index. / Harding, IH; Andrews, ZB; Mata, F; Orlandea, S.; Martínez-Zalacaín, I.; Soriano-Mas, C.; Stice, E.; Verdejo-Garcia, A.

In: International Journal of Obesity, Vol. 42, No. 3, 01.03.2018, p. 448-454.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Brain substrates of unhealthy versus healthy food choices

T2 - Influence of homeostatic status and body mass index

AU - Harding, IH

AU - Andrews, ZB

AU - Mata, F

AU - Orlandea, S.

AU - Martínez-Zalacaín, I.

AU - Soriano-Mas, C.

AU - Stice, E.

AU - Verdejo-Garcia, A.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Background/Objectives:Unhealthy dietary choices are a major contributor to harmful weight gain and obesity. This study interrogated the brain substrates of unhealthy versus healthy food choices in vivo, and evaluated the influence of hunger state and body mass index (BMI) on brain activation and connectivity.Subjects/Methods:Thirty adults (BMI: 18-38 kg m '2) performed a food-choice task involving preference-based selection between beverage pairs consisting of high-calorie (unhealthy) or low-calorie (healthy) options, concurrent with functional magnetic resonance imaging (fMRI). Selected food stimuli were delivered to participants using an MRI-compatible gustometer. fMRI scans were performed both after 10-h fasting and when sated. Brain activation and hypothalamic functional connectivity were assessed when selecting between unhealthy-healthy beverage pairings, relative to unhealthy-unhealthy and healthy-healthy options. Results were considered significant at cluster-based family-wise error corrected P<0.05.Results:Selecting between unhealthy and healthy foods elicited significant activation in the hypothalamus, the medial and dorsolateral prefrontal cortices, the anterior insula and the posterior cingulate. Hunger was associated with higher activation within the ventromedial and dorsolateral prefrontal cortices, as well as lower connectivity between the hypothalamus and both the ventromedial prefrontal cortex and dorsal striatum. Critically, people with higher BMI showed lower activation of the hypothalamus - regardless of hunger state - and higher activation of the ventromedial prefrontal cortex when hungry.Conclusions:People who are overweight and obese have weaker activation of brain regions involved in energy regulation and greater activation of reward valuation regions while making choices between unhealthy and healthy foods. These results provide evidence for a shift towards hedonic-based, and away from energy-based, food selection in obesity.

AB - Background/Objectives:Unhealthy dietary choices are a major contributor to harmful weight gain and obesity. This study interrogated the brain substrates of unhealthy versus healthy food choices in vivo, and evaluated the influence of hunger state and body mass index (BMI) on brain activation and connectivity.Subjects/Methods:Thirty adults (BMI: 18-38 kg m '2) performed a food-choice task involving preference-based selection between beverage pairs consisting of high-calorie (unhealthy) or low-calorie (healthy) options, concurrent with functional magnetic resonance imaging (fMRI). Selected food stimuli were delivered to participants using an MRI-compatible gustometer. fMRI scans were performed both after 10-h fasting and when sated. Brain activation and hypothalamic functional connectivity were assessed when selecting between unhealthy-healthy beverage pairings, relative to unhealthy-unhealthy and healthy-healthy options. Results were considered significant at cluster-based family-wise error corrected P<0.05.Results:Selecting between unhealthy and healthy foods elicited significant activation in the hypothalamus, the medial and dorsolateral prefrontal cortices, the anterior insula and the posterior cingulate. Hunger was associated with higher activation within the ventromedial and dorsolateral prefrontal cortices, as well as lower connectivity between the hypothalamus and both the ventromedial prefrontal cortex and dorsal striatum. Critically, people with higher BMI showed lower activation of the hypothalamus - regardless of hunger state - and higher activation of the ventromedial prefrontal cortex when hungry.Conclusions:People who are overweight and obese have weaker activation of brain regions involved in energy regulation and greater activation of reward valuation regions while making choices between unhealthy and healthy foods. These results provide evidence for a shift towards hedonic-based, and away from energy-based, food selection in obesity.

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U2 - 10.1038/ijo.2017.237

DO - 10.1038/ijo.2017.237

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JF - International Journal of Obesity

SN - 0307-0565

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