Brain structure and neurological and behavioural functioning in infants born preterm

Claire E Kelly, Deanne K. Thompson, Jeanie L.Y. Cheong, Jian Chen, Joy E. Olsen, Abbey L Eeles, Jennifer M. Walsh, Marc L. Seal, Peter J. Anderson, Lex W. Doyle, Alicia J. Spittle

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aim: To examine: (1) relationships between brain structure, and concurrently assessed neurological and behavioural functioning, in infants born preterm at term-equivalent age (TEA; approximately 38–44wks); and (2) whether brain structure–function relationships differ between infants born very (24–29wks) and moderate-late (32–36wks) preterm. Method: A total of 257 infants (91 very preterm, 166 moderate-late preterm; 120 males, 137 females) had structural magnetic resonance imaging (MRI) and neurological and behavioural assessments (Prechtl's general movements assessment, Neonatal Intensive Care Unit Network Neurobehavioral Scale [NNNS] and Hammersmith Neonatal Neurological Examination [HNNE]). Two hundred and sixty-three infants (90 very preterm, 173 moderate-late preterm; 131 males, 132 females) had diffusion MRI and assessments. Associations were investigated between assessment scores and global brain volumes using linear regressions, regional brain volumes using Voxel-Based Morphometry, and white matter microstructure using Tract-Based Spatial Statistics. Results: Suboptimal scores on some assessments were associated with lower fractional anisotropy and/or higher axial, radial, and mean diffusivities in some tracts: NNNS attention and reflexes, and HNNE total score and tone, were associated with the corpus callosum and optic radiation; NNNS quality of movement with the corona radiata; HNNE abnormal signs with several major tracts. Brain structure-function associations generally did not differ between the very and moderate-late preterm groups. Interpretation: White matter microstructural alterations may be associated with suboptimal neurological and behavioural performance in some domains at TEA in infants born preterm. Brain structure–function relationships are similar for infants born very preterm and moderate-late preterm. What this paper adds: Brain volume is not related to neurological/behavioural function in infants born preterm at term. White matter microstructure is related to some neurological/behavioural domains at term. Brain–behaviour relationships are generally similar for infants born very preterm and moderate-late preterm.

Original languageEnglish
Number of pages13
JournalDevelopmental Medicine and Child Neurology
DOIs
Publication statusAccepted/In press - 10 Dec 2018

Cite this

Kelly, C. E., Thompson, D. K., Cheong, J. L. Y., Chen, J., Olsen, J. E., Eeles, A. L., ... Spittle, A. J. (Accepted/In press). Brain structure and neurological and behavioural functioning in infants born preterm. Developmental Medicine and Child Neurology. https://doi.org/10.1111/dmcn.14084
Kelly, Claire E ; Thompson, Deanne K. ; Cheong, Jeanie L.Y. ; Chen, Jian ; Olsen, Joy E. ; Eeles, Abbey L ; Walsh, Jennifer M. ; Seal, Marc L. ; Anderson, Peter J. ; Doyle, Lex W. ; Spittle, Alicia J. / Brain structure and neurological and behavioural functioning in infants born preterm. In: Developmental Medicine and Child Neurology. 2018.
@article{7ff9aa0860b24843aed99cb011e65eee,
title = "Brain structure and neurological and behavioural functioning in infants born preterm",
abstract = "Aim: To examine: (1) relationships between brain structure, and concurrently assessed neurological and behavioural functioning, in infants born preterm at term-equivalent age (TEA; approximately 38–44wks); and (2) whether brain structure–function relationships differ between infants born very (24–29wks) and moderate-late (32–36wks) preterm. Method: A total of 257 infants (91 very preterm, 166 moderate-late preterm; 120 males, 137 females) had structural magnetic resonance imaging (MRI) and neurological and behavioural assessments (Prechtl's general movements assessment, Neonatal Intensive Care Unit Network Neurobehavioral Scale [NNNS] and Hammersmith Neonatal Neurological Examination [HNNE]). Two hundred and sixty-three infants (90 very preterm, 173 moderate-late preterm; 131 males, 132 females) had diffusion MRI and assessments. Associations were investigated between assessment scores and global brain volumes using linear regressions, regional brain volumes using Voxel-Based Morphometry, and white matter microstructure using Tract-Based Spatial Statistics. Results: Suboptimal scores on some assessments were associated with lower fractional anisotropy and/or higher axial, radial, and mean diffusivities in some tracts: NNNS attention and reflexes, and HNNE total score and tone, were associated with the corpus callosum and optic radiation; NNNS quality of movement with the corona radiata; HNNE abnormal signs with several major tracts. Brain structure-function associations generally did not differ between the very and moderate-late preterm groups. Interpretation: White matter microstructural alterations may be associated with suboptimal neurological and behavioural performance in some domains at TEA in infants born preterm. Brain structure–function relationships are similar for infants born very preterm and moderate-late preterm. What this paper adds: Brain volume is not related to neurological/behavioural function in infants born preterm at term. White matter microstructure is related to some neurological/behavioural domains at term. Brain–behaviour relationships are generally similar for infants born very preterm and moderate-late preterm.",
author = "Kelly, {Claire E} and Thompson, {Deanne K.} and Cheong, {Jeanie L.Y.} and Jian Chen and Olsen, {Joy E.} and Eeles, {Abbey L} and Walsh, {Jennifer M.} and Seal, {Marc L.} and Anderson, {Peter J.} and Doyle, {Lex W.} and Spittle, {Alicia J.}",
year = "2018",
month = "12",
day = "10",
doi = "10.1111/dmcn.14084",
language = "English",
journal = "Developmental Medicine and Child Neurology",
issn = "0012-1622",
publisher = "Wiley-Blackwell",

}

Kelly, CE, Thompson, DK, Cheong, JLY, Chen, J, Olsen, JE, Eeles, AL, Walsh, JM, Seal, ML, Anderson, PJ, Doyle, LW & Spittle, AJ 2018, 'Brain structure and neurological and behavioural functioning in infants born preterm' Developmental Medicine and Child Neurology. https://doi.org/10.1111/dmcn.14084

Brain structure and neurological and behavioural functioning in infants born preterm. / Kelly, Claire E; Thompson, Deanne K.; Cheong, Jeanie L.Y.; Chen, Jian; Olsen, Joy E.; Eeles, Abbey L; Walsh, Jennifer M.; Seal, Marc L.; Anderson, Peter J.; Doyle, Lex W.; Spittle, Alicia J.

In: Developmental Medicine and Child Neurology, 10.12.2018.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Brain structure and neurological and behavioural functioning in infants born preterm

AU - Kelly, Claire E

AU - Thompson, Deanne K.

AU - Cheong, Jeanie L.Y.

AU - Chen, Jian

AU - Olsen, Joy E.

AU - Eeles, Abbey L

AU - Walsh, Jennifer M.

AU - Seal, Marc L.

AU - Anderson, Peter J.

AU - Doyle, Lex W.

AU - Spittle, Alicia J.

PY - 2018/12/10

Y1 - 2018/12/10

N2 - Aim: To examine: (1) relationships between brain structure, and concurrently assessed neurological and behavioural functioning, in infants born preterm at term-equivalent age (TEA; approximately 38–44wks); and (2) whether brain structure–function relationships differ between infants born very (24–29wks) and moderate-late (32–36wks) preterm. Method: A total of 257 infants (91 very preterm, 166 moderate-late preterm; 120 males, 137 females) had structural magnetic resonance imaging (MRI) and neurological and behavioural assessments (Prechtl's general movements assessment, Neonatal Intensive Care Unit Network Neurobehavioral Scale [NNNS] and Hammersmith Neonatal Neurological Examination [HNNE]). Two hundred and sixty-three infants (90 very preterm, 173 moderate-late preterm; 131 males, 132 females) had diffusion MRI and assessments. Associations were investigated between assessment scores and global brain volumes using linear regressions, regional brain volumes using Voxel-Based Morphometry, and white matter microstructure using Tract-Based Spatial Statistics. Results: Suboptimal scores on some assessments were associated with lower fractional anisotropy and/or higher axial, radial, and mean diffusivities in some tracts: NNNS attention and reflexes, and HNNE total score and tone, were associated with the corpus callosum and optic radiation; NNNS quality of movement with the corona radiata; HNNE abnormal signs with several major tracts. Brain structure-function associations generally did not differ between the very and moderate-late preterm groups. Interpretation: White matter microstructural alterations may be associated with suboptimal neurological and behavioural performance in some domains at TEA in infants born preterm. Brain structure–function relationships are similar for infants born very preterm and moderate-late preterm. What this paper adds: Brain volume is not related to neurological/behavioural function in infants born preterm at term. White matter microstructure is related to some neurological/behavioural domains at term. Brain–behaviour relationships are generally similar for infants born very preterm and moderate-late preterm.

AB - Aim: To examine: (1) relationships between brain structure, and concurrently assessed neurological and behavioural functioning, in infants born preterm at term-equivalent age (TEA; approximately 38–44wks); and (2) whether brain structure–function relationships differ between infants born very (24–29wks) and moderate-late (32–36wks) preterm. Method: A total of 257 infants (91 very preterm, 166 moderate-late preterm; 120 males, 137 females) had structural magnetic resonance imaging (MRI) and neurological and behavioural assessments (Prechtl's general movements assessment, Neonatal Intensive Care Unit Network Neurobehavioral Scale [NNNS] and Hammersmith Neonatal Neurological Examination [HNNE]). Two hundred and sixty-three infants (90 very preterm, 173 moderate-late preterm; 131 males, 132 females) had diffusion MRI and assessments. Associations were investigated between assessment scores and global brain volumes using linear regressions, regional brain volumes using Voxel-Based Morphometry, and white matter microstructure using Tract-Based Spatial Statistics. Results: Suboptimal scores on some assessments were associated with lower fractional anisotropy and/or higher axial, radial, and mean diffusivities in some tracts: NNNS attention and reflexes, and HNNE total score and tone, were associated with the corpus callosum and optic radiation; NNNS quality of movement with the corona radiata; HNNE abnormal signs with several major tracts. Brain structure-function associations generally did not differ between the very and moderate-late preterm groups. Interpretation: White matter microstructural alterations may be associated with suboptimal neurological and behavioural performance in some domains at TEA in infants born preterm. Brain structure–function relationships are similar for infants born very preterm and moderate-late preterm. What this paper adds: Brain volume is not related to neurological/behavioural function in infants born preterm at term. White matter microstructure is related to some neurological/behavioural domains at term. Brain–behaviour relationships are generally similar for infants born very preterm and moderate-late preterm.

UR - http://www.scopus.com/inward/record.url?scp=85058159741&partnerID=8YFLogxK

U2 - 10.1111/dmcn.14084

DO - 10.1111/dmcn.14084

M3 - Article

JO - Developmental Medicine and Child Neurology

JF - Developmental Medicine and Child Neurology

SN - 0012-1622

ER -