Brain plasticity in the developing brain

Bryan Kolb, Richelle Mychasiuk, Arif Muhammad, Robbin Gibb

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

53 Citations (Scopus)

Abstract

The developing normal brain shows a remarkable capacity for plastic change in response to a wide range of experiences including sensory and motor experience, psychoactive drugs, parent-child relationships, peer relationships, stress, gonadal hormones, intestinal flora, diet, and injury. The effects of injury vary with the precise age-at-injury, with the general result being that injury during cell migration and neuronal maturation has a poor functional outcome, whereas similar injury during synaptogenesis has a far better outcome. A variety of factors influence functional outcome including the nature of the behavior in question and the age at behavioral assessment as well as pre- and postinjury experiences. Here, we review the phases of brain development, how factors influence brain, and behavioral development in both the normal and perturbed brain, and propose mechanisms that may underlie these effects.

Original languageEnglish
Title of host publicationProgress in Brain Research
PublisherElsevier BV
Pages35-64
Number of pages30
DOIs
Publication statusPublished - 1 Jan 2013

Publication series

NameProgress in Brain Research
Volume207
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Keywords

  • Brain development
  • Prefrontal cortex
  • Recovery of function
  • Types of plasticity

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