Brain model state space reconstruction using an LSTM neural network

Yueyang Liu, Artemio Soto-Breceda, Philippa Karoly, David B. Grayden, Yun Zhao, Mark J. Cook, Daniel Schmidt, Levin Kuhlmann

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objective. Kalman filtering has previously been applied to track neural model states and parameters, particularly at the scale relevant to electroencephalography (EEG). However, this approach lacks a reliable method to determine the initial filter conditions and assumes that the distribution of states remains Gaussian. This study presents an alternative, data-driven method to track the states and parameters of neural mass models (NMMs) from EEG recordings using deep learning techniques, specifically a long short-term memory (LSTM) neural network.Approach. An LSTM filter was trained on simulated EEG data generated by a NMM using a wide range of parameters. With an appropriately customised loss function, the LSTM filter can learn the behaviour of NMMs. As a result, it can output the state vector and parameters of NMMs given observation data as the input.Main results. Test results using simulated data yielded correlations withRsquared of around 0.99 and verified that the method is robust to noise and can be more accurate than a nonlinear Kalman filter when the initial conditions of the Kalman filter are not accurate. As an example of real-world application, the LSTM filter was also applied to real EEG data that included epileptic seizures, and revealed changes in connectivity strength parameters at the beginnings of seizures.Significance. Tracking the state vector and parameters of mathematical brain models is of great importance in the area of brain modelling, monitoring, imaging and control. This approach has no need to specify the initial state vector and parameters, which is very difficult to do in practice because many of the variables being estimated cannot be measured directly in physiological experiments. This method may be applied using any NMM and, therefore, provides a general, novel, efficient approach to estimate brain model variables that are often difficult to measure.

Original languageEnglish
Number of pages15
JournalJournal of Neural Engineering
Volume20
Issue number3
DOIs
Publication statusPublished - 1 Jun 2023

Keywords

  • EEG
  • epilepsy
  • LSTM neural network
  • neural mass model
  • neurophysiological process imaging

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