Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1056-1070 |
| Number of pages | 15 |
| Journal | Neuropsychological Rehabilitation |
| Volume | 27 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2017 |
Keywords
- fatigability
- fatigue
- magnetic resonance imaging
- Traumatic brain injury
- vigilance
Cite this
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Brain lesion correlates of fatigue in individuals with traumatic brain injury. / Schönberger, Michael; Reutens, David; Beare, Richard; O'Sullivan, Richard; Rajaratnam, Shantha M W; Ponsford, Jennie.
In: Neuropsychological Rehabilitation, Vol. 27, No. 7, 2017, p. 1056-1070.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Brain lesion correlates of fatigue in individuals with traumatic brain injury
AU - Schönberger, Michael
AU - Reutens, David
AU - Beare, Richard
AU - O'Sullivan, Richard
AU - Rajaratnam, Shantha M W
AU - Ponsford, Jennie
PY - 2017
Y1 - 2017
N2 - The purpose of this study was to investigate the neurological correlates of both subjective fatigue as well as objective fatigability in individuals with traumatic brain injury (TBI). The study has a cross-sectional design. Participants (N = 53) with TBI (77% male, mean age at injury 38 years, mean time since injury 1.8 years) underwent a structural magnetic resonance imaging (MRI) scan and completed the Fatigue Severity Scale (FSS), while a subsample (N = 36) was also tested with a vigilance task. While subjective fatigue (FSS) was not related to measures of brain lesions, multilevel analyses showed that a change in the participants’ decision time was significantly predicted by grey matter (GM) lesions in the right frontal lobe. The time-dependent development of the participants’ error rate was predicted by total brain white matter (WM) lesion volumes, as well as right temporal GM and WM lesion volumes. These findings could be explained by decreased functional connectivity of attentional networks, which results in accelerated exhaustion during cognitive task performance. The disparate nature of objectively measurable fatigability on the one hand and the subjective experience of fatigue on the other needs further investigation.
AB - The purpose of this study was to investigate the neurological correlates of both subjective fatigue as well as objective fatigability in individuals with traumatic brain injury (TBI). The study has a cross-sectional design. Participants (N = 53) with TBI (77% male, mean age at injury 38 years, mean time since injury 1.8 years) underwent a structural magnetic resonance imaging (MRI) scan and completed the Fatigue Severity Scale (FSS), while a subsample (N = 36) was also tested with a vigilance task. While subjective fatigue (FSS) was not related to measures of brain lesions, multilevel analyses showed that a change in the participants’ decision time was significantly predicted by grey matter (GM) lesions in the right frontal lobe. The time-dependent development of the participants’ error rate was predicted by total brain white matter (WM) lesion volumes, as well as right temporal GM and WM lesion volumes. These findings could be explained by decreased functional connectivity of attentional networks, which results in accelerated exhaustion during cognitive task performance. The disparate nature of objectively measurable fatigability on the one hand and the subjective experience of fatigue on the other needs further investigation.
KW - fatigability
KW - fatigue
KW - magnetic resonance imaging
KW - Traumatic brain injury
KW - vigilance
UR - http://www.scopus.com/inward/record.url?scp=84961206634&partnerID=8YFLogxK
U2 - 10.1080/09602011.2016.1154875
DO - 10.1080/09602011.2016.1154875
M3 - Article
VL - 27
SP - 1056
EP - 1070
JO - Neuropsychological Rehabilitation
JF - Neuropsychological Rehabilitation
SN - 0960-2011
IS - 7
ER -